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Last updated on April 18, 2014 at 13:10 EDT

Latest Polyomaviridae Stories

Single Mutation Gives Virus A New Target
2013-10-22 13:34:16

Brown University In a new study published online in the journal PLoS Pathogens, an international team of scientists showed that by swapping a single amino acid they could change the sugar to which the human BK polyomavirus will bind on the surface of cells. The BK polyomavirus lost the ability to bind its usual target sugar and instead “preferred” the same sugar as its cousin SV40 polyomavirus, which is active in monkeys. The researchers were working in cell cultures with safe...

2013-10-08 10:09:58

For more than a decade the research group of Brown University Professor Walter Atwood has doggedly pursued the workings of the JC polyomavirus, which causes a disease called PML that fatally degrades the central nervous system of patients with weakened immune systems. In a study published online Oct. 2 in the Journal of Virology, his team describes how it gains entry into cells: It breaks in via certain receptors of the neurotransmitter serotonin called 5-HT2 receptors. Atwood, lead author...

Bird Virus Found In Dolphin
2013-07-11 12:48:46

Brett Smith for redOrbit.com - Your Universe Online A group of marine biologists announced they have found a stranded dolphin on a San Diego beach that was apparently killed by a virus previously thought to have only a mild effect on mammals. The short-nosed dolphin was apparently killed by a polyomavirus, which is known to cause disease in birds. "It is therefore interesting that this particular polyomavirus appears to be what killed this dolphin," said Simon Anthony, a researcher at...

2013-06-11 14:03:25

The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients – and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease's main attack, that same finding raises new questions about what the mutants are doing instead. Even if they are not the ones killing key brain cells, the mutants are up to...

2013-05-23 08:27:14

June 19-20, 2013 New York Academy of Sciences, New York, NY ATLANTA, May 23, 2013 /PRNewswire/ -- Inhibikase Therapeutics, Inc., an emerging leader in infectious disease treatments, announced today that it will present new results on its antiviral program to 'prevent' PML at an industry conference sponsored by the PML Consortium (composed of Pfizer, Bristol-Meyers Squibb, Roche and Biogen Idec). JC polyomavirus (JCV) is the causative agent of Progressive Multifocal...

2013-04-25 08:34:16

May 11, 2013 Grand Hotel Bristol, Stresa, Italy ATLANTA, April 25, 2013 /PRNewswire/ -- Inhibikase Therapeutics, Inc., an emerging leader in infectious disease, announced today that it will update the scientific and medical community on the development program for IkT-001Pro. IkT-001Pro, a host-directed tyrosine kinase inhibitor in an extended release formulation, is intended to clear JC polyomavirus (JCV) infection, the causative agent of Progressive Multifocal...