Quantcast

Latest Polyomavirus Stories

2011-08-16 06:10:00

ATLANTA, Aug. 16, 2011 /PRNewswire/ -- Inhibikase Therapeutics, Inc., an emerging leader in infectious disease, announced today that it has received FDA clearance to commence a Phase II proof-of-concept trial for its lead compound IkT-001. IkT-001, a host-directed kinase inhibitor, is intended to clear JC polyomavirus (JCV) infection, the causative agent of Progressive Multifocal Leukoencephalopathy (PML). This proof-of-concept trial will be conducted in multiple sclerosis (MS)...

2010-10-22 10:07:25

(Ivanhoe Newswire) -- The JC polyomavirus doesn't strike very often, but when it does, this mean bug can leave a devastating path. The JC polyomavirus is an opportunistic viral infection of the central nervous system. It usually preys on people with weakened immune systems, including people with AIDS, and almost always kills them. Researchers at Brown University, the University of Tubingen in Germany and Imperial College in London got together to study the precise structure and biology of how...

2010-10-20 20:04:56

The JC polyomavirus doesn't strike very often, but it's a mean bug that preys on people with weakened immune systems, including people with AIDS, and almost always kills them. Now an international team of scientists at Brown University, the University of Tbingen in Germany, and Imperial College in London has found a potential Achilles Heel and painted a target on it: The virus must bind to a very specific sugar molecule dangling from the side of the brain cells it attacks. Like the rebel...

2009-10-26 08:00:00

SAN DIEGO, Oct. 26 /PRNewswire/ -- Inhibikase Therapeutics, a specialty pharmaceutical company based in Atlanta, Georgia, will discuss simultaneous antiviral and antibacterial activity from small molecule agents at the 2009 BIOCOM Investor Conference. Employing a host-factor targeted approach, Inhibikase will illustrate the utility of IkT-001 and IkT-041 to treat multiple infectious diseases in humans. The Company's flu program has identified a compound, IkT-041, comparable in activity...

2009-09-24 07:17:30

The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be associated with a rare skin cancer, known as Merkel cell carcinoma, according to a new study published online September 23 in the Journal of the National Cancer Institute. The majority of patients with Merkel cell carcinoma carry MCPyV, but little is known about the polyomavirus' prevalence in the general population and the association between circulating antibodies against MCPyV and the rare skin cancer. Denise...

2009-01-22 09:10:00

Noninvasive screen could improve diagnosis and care of patients with polyomavirus nephropathy A new and simple urine test can detect polyomavirus nephropathy, a relatively new and serious complication that affects up to 9% of kidney transplant recipients, according to a study appearing in the February 2009 issue of the Journal of the American Society Nephrology (JASN). The advance could lead to better diagnosis and treatment of patients with this condition. While polyomaviruses are normally...

2008-09-07 03:00:07

By Valle, Luis Del White, Martyn K; Khalili, Kamel Abstract The human polyomavirus JC (JCV) is a small DNA tumor virus and the etiologic agent of the progressive multifocal leukoencephalopathy. In progressive multifocal leukoencephalopathy, active JCV replication causes the lytic destruction of oligodendrocytes. The normal immune system prevents JCV replication and suppresses the virus into a state of latency so that expression of viral proteins cannot be detected. In a cellular context...

2008-04-25 03:00:20

By Shishido-Hara, Yukiko Higuchi, Kayoko; Ohara, Sinji; Duyckaerts, Charles; Hauw, Jean-Jacques; Uchihara, Toshiki Abstract Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder due to human polyomavirus JC infection in which there are viral inclusions in enlarged nuclei of infected oligodendrocytes. We report that the pathogenesis of this disease is associated with distinct subnuclear structures known as promyelocytic leukemia nuclear bodies (PML-NBs). Postmortem...

2007-06-19 06:00:12

By McCalmont, Vicki Bennett, Kristi Progressive multifocal leukoencephalopathy is a rare, highly fatal demyelinating brain infection caused by the JC virus. This infection is associated with immunosuppressive agents and is emerging in the transplant population. There has never been a documented case of progressive multifocal leukoencephalopathy in a transplant recipient receiving sirolimus. We present a study, in which the JC virus was found in a 68-year-old man who had received a...


Latest Polyomavirus Reference Libraries

45_c8d4395f53eb6d3d4b08458e135e5ef0
2011-02-23 17:31:48

Polyomavirus is the sole genus of viruses within the family Polyomaviridae. Ludwik Gross discovered the first polyomavirus, Murine polyomavirus, in 1963. Many polyomaviruses infect birds and mammals and have been extensively studied as tumor viruses in humans and animals. Polyomaviruses are DNA-based, small, and icosahedral in shape. They can potentially cause tumors and often persist as latent infections in a host without causing disease. There are three major clades or...

45_16476fe85b6c94ca2cddefe0d4dea632
2011-02-17 16:45:25

Merkel cell polyomavirus (MCV or MCPyV), first discovered in January 2008, is one of seven human tumor viruses. It is suspected to cause most of Merkel cell carcinoma which is a rare, aggressive form of skin cancer. Around 80% of Merkel cell carcinoma tumors are found to be infected with MCV. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. Usually the tumors with MCV viruses go through at least two mutations that render the virus...

2011-01-05 16:14:54

The BK virus, a member of the polyomavirus family, has no major consequences of infected except with those that are immunocomprimised or immunosuppressed. The virus was first isolated in 1971 from the urine sample of a renal transplant patient whose initials were B.K. Similar in genome sequences to the JCV virus they are most easily identified and differentiated from each other through serological tests using specific antibodies or through PCR based genotyping approach. Most people are...

More Articles (3 articles) »
Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
Related