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Latest porphyria Stories

2007-06-12 03:00:10

By Masubuchi, Yasuhiro Horie, Toshiharu Cytochrome P450 (P450) enzymes oxidize xenobiotics into chemically reactive metabolites or intermediates as well as into stable metabolites. If the reactivity of the product is very high, it binds to a catalytic site or sites of the enzyme itself and inactivates it. This phenomenon is referred to as mechanism-based inactivation. Many clinically important drugs are mechanism-based inactivators that include macrolide antibiotics, calcium channel...

2005-10-07 13:48:34

HOUSTON "“ (Oct. 7, 2005) -- A research team led by scientists at The University of Texas Medical School at Houston has determined the structure of an enzyme that when defective causes an inherited disease that afflicts sufferers with severe abdominal pain, psychiatric symptoms, skin fragility, and light sensitivity. "Unless prompt and appropriate treatment is given, hereditary coproporphyria can very quickly turn into a life-threatening medical emergency," said C. S. Raman, Ph.D.,...

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2005-07-22 06:40:59

LONDON -- Scientists have found high levels of arsenic in the hair of King George III and say the deadly poison may be to blame for the bouts of apparent madness he suffered. In 1969, researchers proposed the strange behavior of the monarch who reigned during the American Revolution resulted from a rare hereditary blood disorder called porphyria. However, a study this week in The Lancet medical journal found high concentrations of arsenic in the king's hair and contends the severity and...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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