Latest Post-transcriptional modification Stories
A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression.
New study reveals snippets of information contained in dark matter that can alter the way a gene is assembled.
There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process.
Few molecules are more interesting than DNA—except of course RNA. After two decades of research, that "other macromolecule" is no longer considered a mere messenger between glamorous DNA and protein-synthesizing machines.
A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease.
A team of scientists at the CSIC has shown that temperature can play a critical role in the control of splicing.
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing â€“ a critical step in the earliest stage of protein production.
Case Western Reserve University School of Medicine assistant professor in the Center for RNA Molecular Biology, Jeff Coller, Ph.D., and his team discovered that messenger RNA (mRNA) predominately degrade on ribosomes, fundamentally altering a common understanding of how gene expression is controlled within the cell. The study, "Co-translational mRNA decay in Saccharomyces cerevisiae", is published in the latest issue of Nature.
Small, stable RNAs clipped from mature protein-coding RNAs can regulate gene expression.