Quantcast

Latest Post-transcriptional modification Stories

2013-11-11 11:09:02

A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression. The study was published on line in advance of print November 10 in the journal Nature Structural and Molecular Biology. "We uncovered a novel mechanism that allows proteins that direct pre-mRNA splicing – RNA-binding proteins – to induce a regulatory effect from greater distances than was thought possible,"...

Shining Light On Important Role Performed By Dark Matter Within Each Of Our Genes
2013-01-07 09:28:56

University of North Carolina Health Care Research findings from the University of North Carolina School of Medicine are shining a light on an important regulatory role performed by the so-called dark matter, or "junk DNA," within each of our genes. The new study reveals snippets of information contained in dark matter that can alter the way a gene is assembled. "These small sequences of genetic information tell the gene how to splice, either by enhancing the splicing process or...

2012-05-18 23:58:51

Discovery alters prevailing view of splicing regulation and has implications for splicing mutations associated with disease There are always exceptions to a rule, even one that has prevailed for more than three decades, as demonstrated by a Cold Spring Harbor Laboratory (CSHL) study on RNA splicing, a cellular editing process. The rule-flaunting exception uncovered by the study concerns the way in which a newly produced RNA molecule is cut and pasted at precise locations called splice...

2012-03-26 11:03:13

Few molecules are more interesting than DNA–except of course RNA. After two decades of research, that "other macromolecule" is no longer considered a mere messenger between glamorous DNA and protein-synthesizing machines. We now know that RNA has been leading a secret life, regulating gene expression and partnering with proteins to form catalytic ribonucleoprotein (RNP) complexes. One of those RNPs is telomerase, an enzyme that maintains chromosome integrity. In the March 25, 2012,...

2012-01-19 14:55:49

Mutation in 1 copy of U2 snRNA lead to movement problems and early neuron death in mice A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease. The researchers found that a mutation in just one of the many copies of a gene known as U2 snRNAs, which is involved in the intricate processing of protein-encoding RNAs, causes...

2011-09-16 11:26:27

A team of scientists at the CSIC has shown that temperature can play a critical role in the control of splicing. The team led by Josep Vilardell, ICREA scientist at the CSIC's Molecular Biology Institute of Barcelona, has demonstrated that temperature, through its effects on RNA structure, can control how the genetic information will be processed. The results of this work are published this week in Molecular Cell. Hiding intronic cues For some time, scientists have been trying to...

2010-09-25 00:32:36

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing "“ a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell. Nearly 5 percent of the human genome codes for proteins, and scientists are only beginning to understand the role of the rest of the "non-coding" genome. Among the least studied non-coding genes "“ which are transcribed from DNA to RNA...

2009-08-23 13:01:35

Study questions current dogma Case Western Reserve University School of Medicine assistant professor in the Center for RNA Molecular Biology, Jeff Coller, Ph.D., and his team discovered that messenger RNA (mRNA) predominately degrade on ribosomes, fundamentally altering a common understanding of how gene expression is controlled within the cell. The study, "Co-translational mRNA decay in Saccharomyces cerevisiae", is published in the latest issue of Nature. "Many genetic diseases are linked...

2009-01-27 09:52:43

Small, stable RNAs clipped from mature protein-coding RNAs can regulate gene expression Researchers at Cold Spring Harbor Laboratory (CSHL) announced today the discovery of a new class of small RNAs. At the same time, they reported that their discovery suggests the presence of a strikingly novel biochemical pathway for RNA processing in which these and possibly other small RNAs are produced. The research, which is part of a multinational project called ENCODE, also provided information...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.