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Latest Potassium channel Stories

2014-03-05 10:36:54

After a decade of debate, scientists have a clear picture of a controversial protein that helps regulate heart contractions Brandeis University researchers have unlocked a controversial structure in heart cells responsible for regulating heart contractions. For years, scientists have debated how many KCNE1 proteins are required to build a potassium ion channel, theorizing anywhere between one and 14. Now, Brandeis University researchers found that these channels are built with two E1s....

2013-11-25 09:57:46

Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells' pores to generate charges Scientists have figured out how calcium channels – the infinitesimal cell membrane pores that generate electrical signals by gating a charged-particle influx – have solved a "needle in a haystack" problem. The solution to the longstanding riddle is reported in the Nov. 24 advanced online edition of Nature by University of Washington and Howard Hughes Medical...

Water Molecules Control Long Post-activation Recovery Period Of Potassium Channels
2013-07-29 08:51:57

University of Chicago Medical Center Just 12 molecules of water cause the long post-activation recovery period required by potassium ion channels before they can function again. Using molecular simulations that modeled a potassium channel and its immediate cellular environment, atom for atom, University of Chicago scientists have revealed this new mechanism in the function of a nearly universal biological structure, with implications ranging from fundamental biology to the design of...

2013-05-28 10:24:21

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine. The findings, reported this week in the early online version of the Proceedings of the National Academy of Sciences, reveal for the first time the reason the chronic and sometimes debilitating condition occurs. An estimated 5 to 15 percent of Americans hear whistling, clicking,...

2012-07-30 12:15:10

Stowers scientists make a surprising find in study of sex- and aggression-triggering vomeronasal organ The vomeronasal organ (VNO) is one of evolution's most direct enforcers. From its niche within the nose in most land-based vertebrates, it detects pheromones and triggers corresponding basic-instinct behaviors, from compulsive mating to male-on-male death matches. A new study from the Stowers Institute for Medical Research, published online in Nature Neuroscience on July 29, 2012, extends...

2012-07-12 23:01:25

Sophion and CreaCell announced today that the two companies successfully demonstrated the performances of HEK-hKir2.1 cells on QPatch HT. (PRWEB) July 12, 2012 Inward rectifier potassium channels of the Kir2 subfamily are important determinants of the electrical activity of cardiac cells, and mutations of the Kir2.1 channels are associated with familial atrial fibrillation, Andersen-Tawil syndrome and short-QT syndrome. Because human Kir2.1 is a relevant target in preclinical cardiac...

2012-04-23 13:07:39

Tiny pores, or channels, embedded in cell membranes are critical to the healthy functioning of cells. Charged atoms, or ions, move through these channels to generate the electrical signals that allow cells to communicate with one another. New research at Washington University School of Medicine in St. Louis unveils some of the inner workings of certain channels involved in regulating electrical signals in nerve cells, relaxing muscle cells and “tuning” hair cells in the inner...

Cardiac Death Controlled By Circadian Clock
2012-02-23 05:49:51

Researchers have discovered a new link between the time of day and sudden cardiac death (SCD). Abnormal heart rhythms are the most common cause of sudden cardiac death, which happens most often in the morning hours, followed by a smaller peak during the evening hours. This phenomenon has been observed for years but doctors are just now beginning to understand the molecular reason. The researchers found that Krupple-like Factor 15 (KLF15) links the body´s circadian rhythm to the...

2011-11-10 15:40:04

The future of drug design lies in developing therapies that can target specific cellular processes without causing adverse reactions in other areas of the nervous system. Scientists at the Universities of Bristol and Liège in Belgium have discovered how to design drugs to target specific areas of the brain. The research, led by Professor Neil Marrion at Bristol´s School of Physiology and Pharmacology and published in this week´s Proceedings of National Academy of...

2011-07-14 15:21:50

BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood. The study appears in the August 2011 issue of the Journal of General Physiology. Previous research pointed to a possible unified theory of activation gating in K+ channels, with the "activation gate" formed by...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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