Quantcast

Latest Potassium channel Stories

2011-07-14 15:17:23

The human genome encodes 243 voltage-gated ion channels. Mutations in calcium channels can cause severe inherited diseases such as migraine, night blindness, autism spectrum disorders and Timothy syndrome, which leads to severe cardiovascular disorders. Katrin Depil and Anna Stary-Weinzinger together with colleagues from the Department of Pharmacology and Toxicology, University of Vienna analyzed changes in molecular organization of calcium channels caused by Timothy syndrome mutations....

0251d21a28c40bad173f2a861474f1a8
2011-02-08 07:38:20

Berkeley Lab Reports New Fluorescent Assay Reveals TREK1 Mechanism By Lynn Yarris, Berkeley Lab Using a unique and relatively simple cell-based fluorescent assay they developed, scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC), Berkeley have identified a means by which fluoxetine, the active ingredient in Prozac, suppresses the activity of the TREK1 potassium channel. TREK1 activity has been...

2011-01-28 12:39:39

Australian researchers have come one step closer to understanding how the rhythm of the heartbeat is controlled and why many common drugs, including some antibiotics, antihistamines and anti-psychotics, can cause a potentially fatal abnormal heart rhythm. It is estimated around 40-50% of all drugs in development will block one of the main "Ëœchannels' that carries electricity in the heart and, as a result, can cause heart rhythm problems called cardiac arrhythmias. Most sudden...

2011-01-26 13:09:34

New finding adds significantly to our understanding of calcium channel function in health and disease Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The exciting discovery, published this week in the prestigious journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level....

2010-10-26 02:50:03

Scientists are closer to solving one of the many mysteries of multiple sclerosis and other demyelinating diseases, thanks to a recent study conducted at the Salk Institute for Biological Studies. The research revealed a previously unknown connection between two ion channels, which, when misaligned, can cause the many bizarre symptoms that characterize the condition. The findings, reported in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), provide...

ff2e67381585455216857bc766804fd41
2010-06-04 06:50:00

Walter and Eliza Hall Institute scientists have made a significant advance in understanding how potassium channels, which permit the flow of electric currents central to many of the body's biological processes, control the flow of these currents. Dr Jacqui Gulbis from the institute's Structural Biology division, who led the research, said previous studies that had identified what potassium channels look like had provided valuable insights into how they work. However, the way the channels open...

2010-01-25 13:16:49

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels. The studies appear online January 25 in the Journal of General Physiology (www.jgp.org). Falkenburger et al. take advantage of recent progress in fluorescence...

2010-01-05 21:17:13

A new study involving the University of Iowa, Mayo Clinic and two other institutions provides insight on weight control, suggesting that a ATP-sensitive potassium channel critical to survival and stress adaptation can contribute to fat deposition and obesity. The investigation reveals how the ATP-sensitive potassium channel in the heart and skeletal muscles affects the balance between food intake and energy used. The study, which was done in animal models, appears in the January issue of the...

2009-10-26 14:26:00

NEW YORK, Oct. 26 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue. Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development http://www.reportlinker.com/p0156556/Reportlinker-Adds-Ion-Channel-Modulator-Pipelines-Targets-and-Agents-in-Development.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire Ion channels represent a significant opportunity to address an underexploited class of...

58e4a0b52130145d80e6d39129d9e2dd1
2009-06-28 13:02:41

Alcohol's inebriating effects are familiar to everyone. But the molecular details of alcohol's impact on brain activity remain a mystery. A new study by researchers at the Salk Institute for Biological Studies brings us closer to understanding how alcohol alters the way brain cells work. Their findings, published in the current advance online edition of Nature Neuroscience, reveal an alcohol trigger site located physically within an ion channel protein; their results could lead to the...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
Related