Latest Potassium channel Stories
Alcohol's inebriating effects are familiar to everyone. But the molecular details of alcohol's impact on brain activity remain a mystery.
The May 2009 issue of the Journal of General Physiology features an article and accompanying commentary on new experimental evidence that advances previous conclusions about the essential features of the Shaker K+ channel, a voltage-gated potassium (Kv) channel.
HONOLULU, Jan. 28 /PRNewswire/ -- Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief.
Studies at the University of Pennsylvania School of Medicine on brain electrical signaling offer a fresh perspective on vertebrate evolution, provide additional evidence supporting Darwinian views of evolution, and may also lead to more effective treatment of epileptic seizures in infants.
Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition.
Using mice as a model system, researchers at Washington University School of Medicine in St. Louis have identified two key components of the pain cascade (Kv4.2 and ERK) that may act as targets for the design of more effective analgesic drugs with potentially fewer side effects.
One of the biggest mysteries in molecular biology is exactly how ion channels â€“ tiny protein pores through which molecules such as calcium and potassium flow in and out of cells â€“ operate. Such channels can be extremely important; members of the voltage-gated ion channel family are crucial to generating electrical pulses in the brain and heart, carrying signals in nerves and muscles. When channel function goes awry, the resulting diseases â€“ known as channelopathies,...
Research being published in July issue of Diabetes zeros in on who is potentially more susceptible to developing the disease.
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