Latest Potassium channel Stories

2009-04-28 10:21:54

New JGP study advances conclusions about the Shaker Kv channelThe May 2009 issue of the Journal of General Physiology features an article and accompanying commentary on new experimental evidence that advances previous conclusions about the essential features of the Shaker K+ channel, a voltage-gated potassium (Kv) channel.As Richard Horn (Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College) explains in his JGP commentary:"Many of the...

2009-01-28 19:41:00

HONOLULU, Jan. 28 /PRNewswire/ -- Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief. It also holds promise in multiple drug delivery options including nasal spray, transdermal patch, and pills. Data were presented today at the American Academy of Pain Medicine's 25th Annual Meeting. In the study, leconotide, when given intravenously...

2009-01-22 09:00:00

Improvement in brain electrical signaling is critical both for vertebrate evolution and for preventing epileptic seizuresStudies at the University of Pennsylvania School of Medicine on brain electrical signaling offer a fresh perspective on vertebrate evolution, provide additional evidence supporting Darwinian views of evolution, and may also lead to more effective treatment of epileptic seizures in infants. Researchers discovered how evolutionary changes produced a series of improvements in...

2008-01-24 15:20:00

BUFFALO, N.Y. -- Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel pathway unrelated to its COX-2 inhibition. University at Buffalo researchers discovered this unexpected finding while conducting basic research on potassium channels. They found that low concentrations of the drug, corresponding to a standard prescription, reduced the heart rate...

2006-04-06 01:01:12

(RedOrbit) Using mice as a model system, researchers at Washington University School of Medicine in St. Louis have identified two key components of the pain cascade (Kv4.2 and ERK) that may act as targets for the design of more effective analgesic drugs with potentially fewer side effects. The first potential drug target is a potassium channel called Kv4.2. Robert W. Gereau IV, Ph.D., associate professor of anesthesiology and principal investigator on the study, has identified Kv4.2 as a...

2005-10-11 14:06:43

One of the biggest mysteries in molecular biology is exactly how ion channels "“ tiny protein pores through which molecules such as calcium and potassium flow in and out of cells "“ operate. Such channels can be extremely important; members of the voltage-gated ion channel family are crucial to generating electrical pulses in the brain and heart, carrying signals in nerves and muscles. When channel function goes awry, the resulting diseases "“ known as channelopathies,...

2005-06-28 17:05:27

A University of Alberta team of researchers has discovered an additional 2 million Canadians who have a high fat diet or are overweight may be at increased risk for developing type 2 diabetes if they carry a particular type of common specific genetic trait known as a polymorphism. In work published today in the journal, Diabetes, pharmacology professor Peter Light and graduate student Michael Riedel suggest that saturated and trans fats are much more effective activators of a specific...

Word of the Day
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.