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Latest Pre-replication complex Stories

2012-03-06 23:03:37

Molecular-level details of mechanism may point to ways to block unwanted cell division Before any cell - healthy or cancerous - can divide, it has to replicate its DNA. So scientists who want to know how normal cells work - and perhaps how to stop abnormal ones - are keen to understand this process. As a step toward that goal, scientists at the U.S. Department of Energy's Brookhaven National Laboratory and collaborators have deciphered molecular-level details of the complex choreography by...

2010-10-08 02:15:08

Accurate duplication of genetic material and the faithful segregation of chromosomes are critical for cell survival. The initiation of DNA replication is linked both to cell cycle progression and chromatin organization. In plants, animals and other "eukaryotes," the assembly of a multi-protein complex called pre-replicative complex (preRC) is the first step in the initiation of DNA replication. As the name implies, origin recognition complex (ORC) proteins bind to origins of DNA replication....

2010-01-07 14:29:49

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered how a protein long known to be an essential activator of DNA replication actually triggers this process in cells. The protein, called DDK (for Ddf4-dependent protein kinase), is an enzyme that attaches phosphate molecules to other proteins to modify their activity. The CSHL team has found that DDK performs this operation, called phosphorylation, on a protein called Mcm4, specifically within a domain that acts as a built-in...


Word of the Day
out-herod
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.
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