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Latest Precursor mRNA Stories

Unraveling Secrets Of The Mechanism That Snips Our Genes
2013-09-27 09:50:05

Brandeis University Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing. These conditions are difficult to prevent because scientists are still grasping to understand how the splicing process works. Now, researchers from Brandeis University and the University of Massachusetts Medical School have teamed up to unravel...

2012-08-15 11:57:20

Targeted 'negative ASOs' cause missplicing and pathogenesis, providing unique window on disease progression A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases — those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders...

2012-01-19 14:55:49

Mutation in 1 copy of U2 snRNA lead to movement problems and early neuron death in mice A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease. The researchers found that a mutation in just one of the many copies of a gene known as U2 snRNAs, which is involved in the intricate processing of protein-encoding RNAs, causes...

2011-07-14 15:05:40

How the protein U2AF builds mRNA for protein production Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation in Barcelona have discovered how the U2AF protein enables the pre-mRNA* to be spliced to form the mRNA*, which serves as a template for protein synthesis in the body. Splicing requires the cooperation of different...

2011-06-14 01:16:57

Many more hereditary diseases than previously thought may be caused, at least in part, by errors in pre-mRNA splicing, according to a computer analysis by Brown University scientists. That could be good news because research suggests it may be possible to fix bad splicing. A new Brown University computer analysis that predicts the effect of genetic mutations on how the body splices mRNA indicates as many as a third of disease-related mutations may be linked to splicing problems "” more...

2011-03-10 23:36:25

Lasers used to study splicing of pre-messenger RNA molecules From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, researchers have developed a way to use lasers to study the splicing of pre-messenger RNA molecules, an essential process in creating proteins to sustain advanced organisms, including human life. This process of splicing...

2010-11-18 16:32:57

Implications for brain diseases such as epilepsy, according to Penn study Cells have their own version of the cut-and-paste editing function called splicing. Researchers at the University of Pennsylvania School of Medicine have documented a novel form of splicing in the cytoplasm of a nerve cell, which dictates a special form of a potassium channel protein in the outer membrane. The channel protein is found in the dendrites of hippocampus cells -- the seat of memory, learning, and spatial...

2010-09-25 00:32:36

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing "“ a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell. Nearly 5 percent of the human genome codes for proteins, and scientists are only beginning to understand the role of the rest of the "non-coding" genome. Among the least studied non-coding genes "“ which are transcribed from DNA to RNA...

2005-08-15 12:57:11

Pre-messenger RNA (pre-mRNA) splicing is an integral step in gene expression, removing introns that would otherwise disrupt the coding potential of gene transcripts. As published in the August 15th issue of G&D, Drs. Tommaso Villa and Christine Guthrie at UCSF have identified a novel splicing fidelity factor, as well as provide additional evidence for a two-step model of pre-mRNA splicing. The researchers found that deletion of the yeast gene ISY1 reduces the efficiency of the first step...

2005-08-11 19:20:00

SALT LAKE CITY -- In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate). Scientists long have thought the transformation of pre-mRNA into mature mRNA--called splicing--happens only in a cell's nucleus. But using stem cells from human umbilical cord blood to engineer the...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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