Latest Precursor mRNA Stories
Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing.
A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of RNA messages copied from genes.
A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease.
Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation in Barcelona have discovered how the U2AF protein enables the pre-mRNA* to be spliced to form the mRNA*, which serves as a template for protein synthesis in the body.
Many more hereditary diseases than previously thought may be caused, at least in part, by errors in pre-mRNA splicing, according to a computer analysis by Brown University scientists.
From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's.
Cells have their own version of the cut-and-paste editing function called splicing.
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing â€“ a critical step in the earliest stage of protein production.
Pre-messenger RNA (pre-mRNA) splicing is an integral step in gene expression, removing introns that would otherwise disrupt the coding potential of gene transcripts.
In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate). Scientists long have thought the transformation of pre-mRNA into mature mRNA--called splicing--happens only in a cell's nucleus.
- A transitional zone between two communities containing the characteristic species of each.