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Latest Proceedings of the National Academy of Sciences Stories

2013-04-12 15:54:36

Researchers have discovered that rising temperature induces key changes in the dengue virus when it enters its human host, and the findings represent a new approach for designing vaccines against the aggressive mosquito-borne pathogen. The researchers found that the dengue virus particles swell slightly and take on a bumpy appearance when heated to human body temperature, exposing "epitopes," or regions where antibodies could attach to neutralize the virus. The discovery is significant...

2013-04-12 15:46:28

First method to use weather station measurements to obtain daily evaporation rates Researchers at Columbia Engineering and Boston University have developed the first method to map evaporation globally using weather stations, which will help scientists evaluate water resource management, assess recent trends of evaporation throughout the globe, and validate surface hydrologic models in various conditions. The study was published in the April 1 online Early Edition of Proceedings of the...

2013-04-08 12:13:20

3-year study offers new evidence about where scientists should be looking A structural biologist at the Florida State University College of Medicine has made discoveries that could lead scientists a step closer to understanding how life first emerged on Earth billions of years ago. Professor Michael Blaber and his team produced data supporting the idea that 10 amino acids believed to exist on Earth around 4 billion years ago were capable of forming foldable proteins in a high-salt...

2013-04-02 12:32:57

Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers led by those at Baylor College of Medicine in a report that appears online in Proceedings of the National Academy of Sciences. Normally SPOP acts as a tumor suppressor gene by marking SRC-3 for destruction, said Dr. Nicholas Mitsiades, assistant professor of...

2013-03-26 12:30:06

-- Genomic, Molecular Findings by CHOP Researchers Will Help Inform Personalized Medicine -- PHILADELPHIA, March 26, 2013 /PRNewswire-USNewswire/ -- Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations...

2013-03-26 11:08:01

Osteoarthritis is a painful, debilitating illness affecting more than 27 million people in the US Think new discoveries are the bee's knees? This one is even better -- this research out of Rhode Island Hospital is the mice's knees. Researchers have found that adding lubricin, a protein that our bodies naturally produce, to the fluid in our joints may reduce the risk of or even prevent osteoarthritis (OA). The findings, in a paper by Gregory D. Jay, M.D., Ph.D., of the department of...

2013-03-22 09:42:47

Data about defective regulatory protein described in Proceedings of the National Academy of Sciences A little more than a year after the FDA approved Kalydeco (Vx-770), the first drug of its kind to treat the underlying cause of cystic fibrosis, University of Missouri researchers believe they have found exactly how this drug works and how to improve its effectiveness in the future. Described in the current issue of the Proceedings of the National Academy of Sciences, MU researchers have...

2013-03-12 22:45:12

New technique enables more precise design of tissue architecture Researchers at Columbia Engineering have developed a new "plug-and-play" method to assemble complex cell microenvironments that is a scalable, highly precise way to fabricate tissues with any spatial organization or interest–such as those found in the heart or skeleton or vasculature. The study reveals new ways to better mimic the enormous complexity of tissue development, regeneration, and disease, and is published in...

2013-03-04 11:15:32

Shortage of protein TDP-43 causes muscle wasting and stunted nerve cells A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS). ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles...

2013-03-04 11:04:35

A new study has exam­ined how bac­te­ria clog med­ical devices, and the result isn´t pretty. The microbes join to cre­ate slimy rib­bons that tan­gle and trap other pass­ing bac­te­ria, cre­at­ing a full block­age in a star­tlingly short period of time. The find­ing could help shape strate­gies for pre­vent­ing clog­ging of devices such as stents – which are implanted in the body to keep open blood...


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Proceedings of the National Academy of Sciences
2012-05-29 11:19:42

The Proceedings of the National Academy of Sciences of the United States of America (PNAS) is a peer-reviewed scientific journal established in 1914 as the official journal of the US National Academy of Sciences. The first managing editor of the journal was mathematician Edwin Bidwell Wilson. As of May 2012, the editor-in-chief is Inder M. Verma. PNAS is published weekly in print, and daily online in PNAS Early Edition. The first issue of PNAS was published in 1915, and the journal...

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