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Latest Proceedings of the National Academy of Sciences Stories

2013-03-22 09:42:47

Data about defective regulatory protein described in Proceedings of the National Academy of Sciences A little more than a year after the FDA approved Kalydeco (Vx-770), the first drug of its kind to treat the underlying cause of cystic fibrosis, University of Missouri researchers believe they have found exactly how this drug works and how to improve its effectiveness in the future. Described in the current issue of the Proceedings of the National Academy of Sciences, MU researchers have...

2013-03-12 22:45:12

New technique enables more precise design of tissue architecture Researchers at Columbia Engineering have developed a new "plug-and-play" method to assemble complex cell microenvironments that is a scalable, highly precise way to fabricate tissues with any spatial organization or interest–such as those found in the heart or skeleton or vasculature. The study reveals new ways to better mimic the enormous complexity of tissue development, regeneration, and disease, and is published in...

2013-03-04 11:15:32

Shortage of protein TDP-43 causes muscle wasting and stunted nerve cells A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS). ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles...

2013-03-04 11:04:35

A new study has exam­ined how bac­te­ria clog med­ical devices, and the result isn´t pretty. The microbes join to cre­ate slimy rib­bons that tan­gle and trap other pass­ing bac­te­ria, cre­at­ing a full block­age in a star­tlingly short period of time. The find­ing could help shape strate­gies for pre­vent­ing clog­ging of devices such as stents – which are implanted in the body to keep open blood...

2013-02-21 11:34:39

Molecular switch promises new targets for diagnosis and therapy Fetal alcohol syndrome is the leading preventable cause of developmental disorders in developed countries. And fetal alcohol spectrum disorder (FASD), a range of alcohol-related birth defects that includes fetal alcohol syndrome, is thought to affect as many as 1 in 100 children born in the United States. Any amount of alcohol consumed by the mother during pregnancy poses a risk of FASD, a condition that can include the...

2013-02-19 10:14:44

Results in Proceedings of the National Academy of Sciences highlight the beneficial effects of EBI-005 rationally-designed to target and block IL-1 for ocular inflammation Eleven Biotherapeutics, a biopharmaceutical company creating novel and differentiated protein-based biotherapeutics, has published preclinical data in Proceedings of the National Academy of Sciences (PNAS) showing beneficial effects of EBI-005, the first rationally-designed topically administered IL-1 protein for the...

2013-02-19 10:07:52

New study reveals how control of brain blood flow develops with age A new study by Columbia Engineering researchers finds that the infant brain does not control its blood flow in the same way as the adult brain. The paper, which the scientists say could change the way researchers study brain development in infants and children, is published in the February 18 Early Online edition of Proceedings of the National Academy of Sciences (PNAS). "The control of blood flow in the brain is very...

2013-02-05 10:28:21

Surprising result suggests that enhancing these mutations´ impact could offer a new way to treat cancer. A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled growth. Cancer biologists have largely ignored the other mutations, believing they had little or no impact on cancer progression. But a new study from...

2013-01-23 11:53:54

The amount of rainfall and number of tropical storms during the summer monsoon season greatly impact the agriculture, economy, and people in Asia. Though meteorologists and climate scientists have worked for years to develop helpful prediction systems, seasonal predictions of these two types of weather phenomena are still poor. Scientists working at the International Pacific Research Center, University of Hawaii at Manoa, have now made a promising breakthrough for predicting in spring both...

2012-09-20 16:58:57

MGH study identifies components responsible for therapy-blocking solid stress, suggests therapeutic strategies It's a high-pressure environment within solid tumors. Abnormal blood and lymphatic vessels cause fluids to accumulate, and the uncontrolled proliferation of cancer cells within limited space leads to the buildup of what is called solid stress. Both types of pressure can interfere with the effectiveness of anticancer treatments, but while strategies have been developed that reduce...


Latest Proceedings of the National Academy of Sciences Reference Libraries

Proceedings of the National Academy of Sciences
2012-05-29 11:19:42

The Proceedings of the National Academy of Sciences of the United States of America (PNAS) is a peer-reviewed scientific journal established in 1914 as the official journal of the US National Academy of Sciences. The first managing editor of the journal was mathematician Edwin Bidwell Wilson. As of May 2012, the editor-in-chief is Inder M. Verma. PNAS is published weekly in print, and daily online in PNAS Early Edition. The first issue of PNAS was published in 1915, and the journal...

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Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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