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Latest Proceedings of the National Academy of Sciences Stories

2012-05-07 20:30:41

Such deletions could confer survival advantage on tumors, a challenge to '2-hit theory' of tumor suppressor action Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer types contain areas harboring multiple functionally linked genes whose loss, they posit, confers a survival advantage on growing tumors. Looking...

2012-05-04 09:22:33

A team led by Johns Hopkins engineers has discovered some previously unknown properties of a common memory material, paving the way for development of new forms of memory drives, movie discs and computer systems that retain data more quickly, last longer and allow far more capacity than current data storage media. The work was reported April 16 in the online edition of Proceedings of the National Academy of Sciences. The research focused on an inexpensive phase-change memory alloy...

2012-05-02 21:26:48

Current nanomedicine research has focused on the delivery of established and novel therapeutics. But a UNC team is taking a different approach. They developed nanoparticle carriers to successfully deliver therapeutic doses of a cancer drug that had previously failed clinical development due to pharmacologic challenges. They report their proof of principle findings in the April 30, 2012 early online edition of Proceedings of the National Academy of Sciences. Wortmannin is a drug that was...

Novel Method To Identify Sources Of Global Sea Level Rise
2012-04-24 11:08:34

As the Earth's climate warms, a melting ice sheet produces a distinct and highly non-uniform pattern of sea-level change, with sea level falling close to the melting ice sheet and rising progressively farther away. The pattern for each ice sheet is unique and is known as its sea level fingerprint. Now, a group of geophysicists from the University of Toronto, Harvard and Rutgers Universities have found a way to identify the sea level fingerprint left by a particular ice sheet, and possibly...

2012-04-10 08:58:35

Molecular mechanisms involved in the switch-on of the temperature sensor TRPM2 by hydrogen peroxide have been clarified Macrophages playing an important role in the immune system eat and fight against pathogens and foreign substances in the very beginning of infection. In this condition, macrophages produce reactive oxygen species for sterilization. However, the relation with the temperature sensor was not previously known. Professor Makoto TOMINAGA from National Institute for...

Scientists Uncover Novel Gene's Key Role In Type 2 Diabetes
2012-04-10 03:32:06

Using computational methods, Stanford University School of Medicine investigators have strongly implicated a novel gene in the triggering of type-2 diabetes. Their experiments in lab mice and in human blood and tissue samples further showed that this gene not only is associated with the disease, as predicted computationally, but is also likely to play a major causal role. In a study published online April 9 in Proceedings of the National Academy of Sciences, the researchers combed through...

2012-04-03 11:33:42

Researchers from the Department of Chemistry and Molecular Biology at the University of Gothenburg have managed for the first time to obtain detailed information about the role of the protein metastasin in the spread of tumor cells. Published recently in the renowned Proceedings of the National Academy of Sciences (PNAS), the study paves the way for the development of new drugs. Metastasin is a protein with a key role in the spread of tumor cells. Previous research has shown that it is...

2012-04-03 08:54:51

Fruit flies offer insights on aging Scientists from the Florida campus of The Scripps Research Institute have shown in animal models that the loss of memory that comes with aging is not necessarily a permanent thing. In a new study published this week in an advance, online edition of the journal Proceedings of the National Academy of Sciences, Ron Davis, chair of the Department of Neuroscience at Scripps Florida, and Ayako Tonoki-Yamaguchi, a research associate in Davis's lab, took a...

2012-03-26 23:38:26

What do changes in weather and stressed-out birds have to do with your health? In a study in Proceedings of the National Academy of Sciences, Jeffry Shaman of Columbia University and Marc Lipsitch of Harvard University are beginning to see a new link between La Niña conditions and outbreaks of the flu that could help governments and public health officials determine when the next pandemic will strike. To examine the connection between La Niña and flu...


Latest Proceedings of the National Academy of Sciences Reference Libraries

Proceedings of the National Academy of Sciences
2012-05-29 11:19:42

The Proceedings of the National Academy of Sciences of the United States of America (PNAS) is a peer-reviewed scientific journal established in 1914 as the official journal of the US National Academy of Sciences. The first managing editor of the journal was mathematician Edwin Bidwell Wilson. As of May 2012, the editor-in-chief is Inder M. Verma. PNAS is published weekly in print, and daily online in PNAS Early Edition. The first issue of PNAS was published in 1915, and the journal...

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