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Latest Proopiomelanocortin Stories

2014-08-04 09:15:31

Yale University Preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain, according to a new study by Yale School of Medicine researchers. Published in the Aug. 1 issue of The Journal of Clinical Investigation (JCI), the study showed that when the researchers blocked the effects of the nuclear receptor PPARgamma in a small number of brain cells in mice, the animals ate less and became...

2012-10-25 00:01:53

Obesity is a chronic metabolic disorder that affects half a billion people worldwide. Managing obesity is difficult, as many patients rebound to their pre-treatment weight. There is a hypothesis that chronic weight gain causes the body to adopt a state that supports excess weight. In a study published in the Journal of Clinical Investigation, researchers led by Malcolm Low at the University of Michigan challenged this hypothesis by developing a mouse model of obesity where the...

2011-07-14 07:14:44

(Ivanhoe Newswire)--For some time scientists have known the hormone leptin has acted in the brain to prevent obesity, but the mystery remains as to whether or not this is a natural weight loss treatment. Leptin has been described as our starvation hormone. It tells your brain when you have stored enough energy in your fat cells to engage in normal metabolic processes. Senior study author Dr. Bradford B. Lowell from Beth Israel Deaconess Medical Center and Harvard Medical School was quoted...

2011-07-13 23:31:09

Scientists have known for some time that the hormone leptin acts in the brain to prevent obesity, but the specific underlying neurocircuitry has remained a mystery. Now, new research published by Cell Press in the July 14 issue of the journal Neuron reveals neurobiological mechanisms that may underlie the antiobesity effects of leptin. "Leptin is a hormone that is secreted by fat cells and acts at its receptor in the brain to decrease food intake and promote energy expenditure," explains...

2011-06-13 07:49:44

(Ivanhoe Newswire) -- Smokers may die young, but they also die thinner than non-smokers. Scientists have discovered exactly how nicotine suppresses the appetite, and these findings suggest it might be possible to develop a drug that would help smokers and non-smokers stay thin. Nicotine activates a small set of neurons in a part of the hypothalamus that tells the body it's had enough to eat. Nicotine accomplishes this by activating a different set of receptors on the surface of neurons aside...

2011-06-08 22:01:36

Obesity among people who eat a high-fat diet may involve injury to neurons, or nerve cells, in a key part of the brain that controls body weight, according to the authors of a new animal study. The results will be presented Tuesday at The Endocrine Society's 93rd Annual Meeting in Boston. "The possibility that brain injury may be a consequence of the overconsumption of a typical American diet offers a new explanation for why sustained weight loss is so difficult for most obese individuals to...

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2011-06-07 08:00:04

Researchers decode an important mechanism through which insulin in the hypothalamus controls the body's energy balance Fat-rich food makes you fat. Behind this simple equation lie complex signaling pathways, through which the neurotransmitters in the brain control the body's energy balance. Scientists at the Cologne-based Max Planck Institute for Neurological Research and the Cluster of Excellence in Cellular Stress Responses in Ageing-associated Diseases (CECAD) at the University of Cologne...

2010-11-10 17:44:46

New findings by researchers at UT Southwestern Medical Center suggest that serotonin "“ a brain chemical known to help regulate emotion, mood and sleep "“ might also have anti-diabetic properties. The findings, appearing online this week in Nature Neuroscience, also offer a potential explanation for why individuals prescribed certain kinds of anti-psychotic drugs that affect serotonin signaling sometimes have problems with their metabolism, including weight gain and the...

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2008-11-25 13:01:37

Once hailed as a miracle weight-loss drug, Fen-phen was removed from the market more than a decade ago for inducing life-threatening side effects, including heart valve lesions. Scientists at UT Southwestern Medical Center are trying to understand how Fen-phen behaves in the brain in order to develop safer anti-obesity drugs with fewer side effects.  In a study appearing in the Nov. 25 issue of Neuron, the researchers define a circuit in the brain that explains the ways fenfluramine, a...

2008-03-21 03:00:15

By Abdel-Malek, Zalfa A Knittel, James; Kadekaro, Ana Luisa; Swope, Viki B; Starner, Renny ABSTRACT Cutaneous pigmentation is the major photoprotective mechanism against the carcinogenic and aging effects of UV. Epidermal melanocytes synthesize the pigment melanin, in the form of eumelanin or pheomelanin. Synthesis of the photoprotective eumelanin by human melanocytes is regulated mainly by the melanocortins alpha- melanocortin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which bind...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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