Latest propylthiouracil Stories

2012-08-13 12:56:14

Endocrine Society revises clinical practice guideline for management of thyroid dysfunction The Endocrine Society has made revisions to its 2007 Clinical Practice Guideline (CPG) for management of thyroid disease during pregnancy and postpartum. The CPG provides recommendations for diagnosis and treatment of patients with thyroid-related medical issues just before and during pregnancy and in the postpartum interval. Thyroid hormone contributes critically to normal fetal brain...

2009-06-03 13:05:33

The U.S. Food and Drug Administration warned health care professionals Wednesday of the risk of serious liver injury from the use of an anti-thyroid drug. After analyzing adverse event reports, the FDA has identified an increased risk of liver injury with propylthiouracil (commonly known as PTU) when compared to an alternative treatment for Graves' disease, methimazole, Dr. Amy Egan of the FDA's Center for Drug Evaluation and Research said. Health care professionals should carefully consider...

2009-04-09 07:55:53

Liver failure results from use of a medication to treat thyroid disease in children, two doctors caution in a report accounted by the Associated Press. Typically, doctors initially opt to prescribe propylthiouracil or methimazole when treating children diagnosed with Graves' disease, the most common cause of an overactive thyroid.  Secondly, a doctor might prescribe surgery or radioactive iodine.  Reports over the last 60 years have surfaced connecting the use of propylthiouracil,...

2007-06-28 12:05:17

By Zoeller, R Thomas Tyl, Rochelle W; Tan, Shirlee W This article reviews current rodent screens and tests to detect thyroid toxicants. Many points of disruption for thyroid toxicants are outlined and include: (a) changes in serum hormone level; (b) thyroperoxidase inhibitors; (c) the perchlorate discharge test; (d) inhibitors of iodide uptake; (e) effects on iodothyronine deiodinases; (f) effects on thyroid hormone action; and (g) role of binding proteins (e.g., rodent transthyretin). The...

Word of the Day
  • A goblin in English folklore, often appearing in the shape of a large dog and believed to portend imminent death or misfortune.
  • A ghost, wraith, hobgoblin, elf, or spirit.
The origin of 'barghest' is not known, but it may be from perhaps burh-ghest, town-ghost, or German Berg-geist (mountain spirit) or Bär-geist (bear-spirit).