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Latest Protease Stories

2012-10-10 10:27:08

“Molecular sled” carries viral enzyme along DNA to find and interact with targets; findings suggest mechanism may be universal Scientists at the U.S. Department of Energy´s (DOE) Brookhaven National Laboratory, with collaborators from Harvard University, the University of Madrid, Princeton University, and the University of Zurich, have discovered a new mechanism that may alter principle understandings of molecular interactions within a cell´s nucleus. The discovery...

2012-07-10 15:24:19

Exploiting "molecular glues" to target disease relevant proteolytic enzymes Scientists at the University Medical Center of Johannes Gutenberg University Mainz in Germany identified a novel strategy to target the oncologically relevant protein-cleaving enzyme Taspase1. Taspase1 levels are not only elevated in cancer cells of patients with head and neck tumors and other solid malignancies but the enzyme is also critical for the development of leukemias. Central to this concept is the...

2012-07-04 23:03:01

The novel Natural Sciences Repository aims to provide reliable information on various areas of scientific interest and presents it's content in the simplest words and terms possible. The site has now added the categories Acid Alkaline Diet and Enzyme to it's Acid section. The Diet category contains scientific information on the acid alkaline diet, which is a form of dietary practice based on the belief that several foods we consume leave an alkaline residue in the body. The second newly...

2012-04-03 09:22:40

A previously unknown serine protease forms part of the antibacterial defense arsenal of neutrophil granulocytes Neutrophil granulocytes comprise important defenses for the immune system. When pathogenic bacteria penetrate the body, they are the first on the scene to mobilize other immune cells via signal molecules, thereby containing the risk. To this end, they release serine proteases — enzymes that cut up other proteins to activate signal molecules. Scientists at the Max Planck...

2012-01-26 15:14:29

A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit this metastasis in patients with tumors. A cell that breaks away from the primary tumor and finds itself in the alien environment of the bloodstream or a new organ, normally is destroyed by a process known as apoptosis. But tumor cells that express high levels of a...

2011-09-27 15:02:32

Researchers at the Perelman School of Medicine at the University of Pennsylvania, Monash University, and Virginia Tech have used a set of novel inhibitors to analyze how the malaria parasite, Plasmodium falciparum, uses enzymes to chew up human hemoglobin from host red blood cells as a food source. They have validated that two of these parasite enzymes called peptidases are potential anti-malarial drug targets. The research appeared in the Aug. 15 early online issue of the Proceedings of the...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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