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Latest Proteases: Essential Tools of Angiogenesis Stories

2012-07-26 01:10:11

There are many factors that affect tumor invasion, the process where a tumor grows beyond the tissue where it first developed. While factors like genetics, tissue type and environmental exposure affect tumor metastasis and invasion, physical forces like fluid flow remain a poorly understood component of tumor invasion. A new video article in JoVE, the Journal of Visualized Experiments, describes a novel procedure that allows researchers to study and test the microenvironment of a growing...

2012-03-29 21:48:03

Max Planck researchers unravel a critical regulatory mechanism controlling blood vessel growth that might help solve drug resistance problems in the future Angiogenesis, the growth of new blood vessels, is a complex process during which different signalling proteins interact with each other in a highly coordinated fashion. The growth factor VEGF and the Notch signalling pathway both play important roles in this process. VEGF promotes vessel growth by binding to its receptor, VEGFR2, while...

2012-01-18 06:29:54

(Ivanhoe Newswire) — A new study found that a group of little-explored cells in the tumor microenvironment can likely serve as gatekeepers against cancer progression and metastasis. One known way of treating cancer is by targeting angiogenesis, or blood vessel growth. Raghu Kalluri, MD, PhD, Chief of the Division of Matrix Biology at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School (HMS) and colleagues, hypothesized whether targeting a...

2011-11-28 20:29:27

Scientists at the University of North Carolina at Chapel Hill School of Medicine have identified a cellular protein that plays a central role in the formation of new blood vessels. The molecule is the protein Shc (pronounced SHIK), and new blood vessel formation, or angiogenesis, is seriously impaired without it. The study, which appeared online November 16, 2011 in the journal Blood, was led by associate professor of cell and molecular physiology at UNC, Ellie Tzima, PhD, who is also a...

2011-08-10 06:45:25

(Ivanhoe Newswire)--Researchers are gaining insight on how to slow the growth of tumors via angiogenesis inhibitors. Angiogenesis is the process involving the growth of new blood vessels from pre-existing ones. This is a normal process for growth and development as well as wound healing. Angiogenesis has also been proven to be a fundamental step in transitioning tumors from a dormant state to a malignant one which leads to the use of inhibitors which eliminate blood supply to these tumors....

2011-08-08 06:45:41

Shows promise for development of anti-tumor drugs Researchers have gained a new understanding of the way in which growing tumors are fed and how this growth can be slowed via angiogenesis inhibitors that eliminate the blood supply to tumors. This represents a step forward towards developing new anti-cancer drug therapies. The results of this study have been published today in the September issue of The American Journal of Pathology. "The central role of capillary sprouting in tumor...

2011-07-02 02:29:20

Natural plant compound blocks vessel growth by interfering with cellular adhesion Massachusetts General Hospital (MGH) researchers have discovered the first of an entirely new class of antiangiogenesis drugs "“ agents that interfere with the development of blood vessels. In a report in Proceedings of the National Academy of Sciences/Early Edition, the investigators describe how a compound derived from a South American tree was able, through a novel mechanism, to interfere with blood...

2011-06-23 07:30:00

BARCELONA, Spain, June 23, 2011 /PRNewswire/ -- CureFAKtor Pharmaceuticals, LLC, a privately-held biopharmaceutical company focused on the research and development of Focal Adhesion Kinase (FAK) inhibitors for cancer, today presented pre-clinical research results at the European Society for Medical Oncology (ESMO) 13th World Congress on Gastrointestinal Cancer in Barcelona, Spain demonstrating that novel FAK inhibitors targeting the binding site of vascular endothelial growth factor...

2011-06-06 17:35:52

Scientists at the Walter and Eliza Hall Institute have discovered a key molecule needed to kill the blood vessels that supply tumors. The research team from the institute's Molecular Genetics of Cancer and Cancer and Haematology divisions found that for anti-cancer therapies that target tumor blood vessels to work the death- inducing molecule Bim is required. The finding could lead to improved anti-cancer treatments that are based on a two- or three-pronged attack on both the tumor and its...


Word of the Day
abrosia
  • Wasting away as a result of abstinence from food.
The word 'abrosia' comes from a Greek roots meaning 'not' and 'eating'.