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Last updated on April 18, 2014 at 9:36 EDT

Latest Proteasome Stories

Key To Controlling Fruit Ripening Could Be In The Functions Of Chloroplasts
2012-11-01 14:51:47

University of Leicester Biologists may have unearthed the potential to manipulate the functions of chloroplasts, the parts of plant cells responsible for photosynthesis. Researchers in the University of Leicester's Department of Biology discovered that chloroplasts are affected by the ubiquitin proteasome system (UPS) — a process which causes the breakdown of unwanted proteins in cells, previously thought to only act on central parts of the cell. As a result, the researchers...

2012-06-07 02:28:49

TORONTO, June 7, 2012 /PRNewswire/ -- The Ontario Institute for Cancer Research (OICR) today announced $1.5 million in funding over three years for the development of a new drug by Toronto-based Fluorinov Pharma, Inc. The drug, called FV-162, is a highly potent, orally-delivered small molecule proteasome inhibitor with significant advantages over drugs currently used to treat multiple myeloma and some forms of Non-Hodgkin's lymphoma. "Our investment in Fluorinov Pharma Inc. will move FV-162...

2012-03-29 02:26:09

SOUTH SAN FRANCISCO, Calif., March 29, 2012 /PRNewswire/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced the publication of an article in Cell, describing the crystal structures of two forms of the proteasome found in mammalian cells: the constitutive proteasome, expressed by the majority of cells in the body, and the immunoproteasome, expressed in cells derived from the bone marrow, including T-cells and B-cells, two types of white blood cells. In addition, this work includes...

2012-03-19 16:58:18

Study outlines new method to test a tumor's resistance to an experimental therapy and pinpoint the genetic culprit before testing the drug in patients–providing a new path toward personalized medicine Drug resistance is a serious problem for cancer patients–over time, a therapy that was once providing some benefit simply stops working. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) recently discovered how cancer cells develop resistance to a drug...

2012-01-23 22:29:14

Defective proteins that are not disposed of by the body can cause diseases such as Alzheimer's or Parkinson's. Scientists at the Max Planck Institute (MPI) of Biochemistry recently succeeded in revealing the structure of the cellular protein degradation machinery (26S proteasome) by combining different methods of structural biology. The results of collaboration with colleagues from the University of California, San Francisco and the Swiss Federal Institute of Technology Zurich (ETH...

2012-01-12 12:18:26

Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine. Dr. Shyamal Desai and her co-investigators from the Louisiana State University School of Medicine in New Orleans, the University of Pennsylvania School of Medicine in...

2012-01-12 11:38:47

Berkeley Researchers Provide Detailed Look at Proteasome´s Regulatory Particle Important new information on one of the most critical protein machines in living cells has been reported by a team of researchers with the U.S. Department of Energy´s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. The researchers have provided the most detailed look ever at the “regulatory particle” used by the protein machines known as...

2012-01-03 14:04:08

Research led by Shyamal Desai, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, has discovered a key change in the body's defense system that increases the potential for breast cancer to spread to other parts of the body. The results, reported for the first time, are featured in the January 2012 issue of Experimental Biology and Medicine. For cancer cells shape matters. All cells contain a protein cytoskeleton that acts as a scaffold...

2011-11-07 16:40:39

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell. Their findings indicate that the capture and removal of such aggregates is mediated by the phosphorylation of a protein called p62, opening the door to new avenues for treating neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. One of the most important activities of a cell is the...

2011-09-27 18:01:28

A study by scientists at the University of California, San Diego and UC Irvine has identified an enzyme called a proteasome phosphatase that appears to regulate removal of damaged proteins from a cell. The understanding of how this process works could have important implications for numerous diseases, including cancer and Parkinson's disease. The study — led by Jack E. Dixon, PhD, professor of Pharmacology, Cellular & Molecular Medicine, and Chemistry/Biochemistry at the...