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Latest Proteasome Stories

2010-05-20 17:01:00

EMERYVILLE, Calif., May 20 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced the presentation of several studies evaluating carfilzomib, a selective, next-generation proteasome inhibitor, at the 46th American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8, 2010 in Chicago, IL. Presentations will highlight data from the carfilzomib development program in patients with relapsed/refractory multiple myeloma and solid tumors. Each presentation...

2010-03-03 05:00:00

BOSTON and SAN DIEGO, March 3 /PRNewswire/ -- Stemgent, Inc., a biotechnology company based in San Diego, California, and Boston, Massachusetts, USA, announced today the formation of Ubiquigent Ltd, a new biotechnology company based in Dundee, Scotland. As part of the agreement, Stemgent will invest approximately $4.5 million (3 million pounds Sterling) in the new venture over the next three years. According to the terms of the agreement, Ubiquigent will produce biological products and...

2010-01-15 17:35:50

Proteosome inhibitors can rescue mutant proteins without altering the DNA of mutant genes Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins. In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into...

2009-12-07 14:17:48

Carfilzomib induces a response in 45 percent of patients and reduces neuropathy The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers reported today at the 51st Annual Meeting of the American Society of Hematology. The updated data from the 17-site study focuses on patients with relapsed or resistant multiple myeloma who have received one to...

2009-11-16 08:29:00

EMERYVILLE, Calif., Nov. 16 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced that the company has completed its acquisition of Proteolix, Inc., a privately held biopharmaceutical company focused on discovering and developing novel therapies that target the proteasome for the treatment of hematological malignancies and solid tumors. "With the close of this strategic transaction, Onyx reaches an important milestone in its evolution as a leading...

2009-11-05 13:23:33

A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer. The study drug, Bortezomib, was found to be effective against bone cancer in human cancer cell studies and in mice. While key experiments were in animals, the cancer studied closely resembled the human form and the drug has already been proven to be safe in human...

2009-10-17 08:00:00

SOUTH SAN FRANCISCO, Oct. 17 /PRNewswire/ -- Proteolix, Inc. today announced that data from preclinical studies of carfilzomib and PR-957 will be presented at the 2009 ACR/ARHP Annual Scientific Meeting on October 16 - 21 in Philadelphia, PA. Carfilzomib is the first in a new class of selective, irreversible proteasome inhibitors, and is currently enrolling patients in multiple oncology clinical trials, including a Phase 2 study in patients with relapsed and refractory multiple...

2009-10-12 06:00:00

SOUTH SAN FRANCISCO, Calif., Oct. 12 /PRNewswire/ -- Proteolix, Inc. today announced that it has signed a definitive agreement to be acquired by Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX). Proteolix is a privately-held biopharmaceutical company focused on discovering and developing novel therapies that target the proteasome for the treatment of hematological malignancies and solid tumors. Proteolix's lead compound, carfilzomib, is a proteasome inhibitor currently in multiple clinical...

2009-10-12 05:58:00

EMERYVILLE, Calif., Oct. 12 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced that it has signed a definitive agreement to acquire Proteolix, Inc., a privately held biopharmaceutical company focused on discovering and developing novel therapies that target the proteasome for the treatment of hematological malignancies and solid tumors. Proteolix's lead compound, carfilzomib, is a proteasome inhibitor currently in multiple clinical trials, including...

2009-09-21 13:47:42

Caspase-3 Cleaves in Unforeseen Ways Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called N-terminomics, Guy Salvesen, Ph.D., professor and director of the Apoptosis and Cell Death Research program of Burnham's NCI-designated Cancer Center, and colleagues determined the cleavage sites on target proteins and found,...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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