Latest Proteasome Stories
Diet and lifestyle may play a much more significant role in a personâ€™s ability to respond favourably to certain drugs, including some cancer therapies, than previously understood, say scientists.
An anti-cancer compound derived from bacteria dwelling in ocean-bottom sediments appears in laboratory tests to be a potent killer of drug-resistant multiple myeloma cells, and potentially with less toxicity than current treatments, report Dana-Farber Cancer Institute researchers in the November issue of Cancer Cell.
NIPA is part of a molecular complex that triggers degradation of cyclin B1 during the cell's 'resting' phase, but allows it to accumulate as the cell gets ready to divide;
Dr. Craig Peterson and colleagues have identified an S. pombe ubiquitin ligase that is required for heterochromatin formation and gene silencing. The authors purified the heterochromatin assembly protein, Rik1, along with two novel Rik-1 associated proteins that proved essential for H3-K9 methylation and centromere silencing. Intruigingly, they also found a novel Rik1-associated E3 ligase that is necessary for heterochromatin assembly.
Researchers eager to test laboratory findings in patient trials.
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