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Last updated on April 24, 2014 at 17:35 EDT

Latest Proteasome Stories

2005-07-18 05:47:48

Cells control mitosis (cell division) by assembling a biochemical switch to block it or by disassembling the switch to trigger it, according to investigators at St. Jude Children's Research Hospital and the Technical University of Munich. The researchers found that when the switch called SCFNIPA is intact, levels of an enzyme called cyclin B1 drop, preventing the enzyme from activating a third protein called Cdk1. By blocking the interaction between cyclin B1 and Cdk1, SCFNIPA prevents the...

2005-07-14 16:40:00

Dr. Craig Peterson and colleagues have identified an S. pombe ubiquitin ligase that is required for heterochromatin formation and gene silencing. The authors purified the heterochromatin assembly protein, Rik1, along with two novel Rik-1 associated proteins that proved essential for H3-K9 methylation and centromere silencing. Intruigingly, they also found a novel Rik1-associated E3 ligase that is necessary for heterochromatin assembly. "These data identify a cullin-dependent E3 ligase as a...

2005-06-02 23:26:36

BOSTON - A novel strategy devised by Dana-Farber Cancer Institute scientists has proved highly effective in killing drug-resistant multiple myeloma cells in the laboratory and could open a new form of attack on the deadly blood cancer, they report. Highly encouraged by the findings, the researchers hope to move rapidly to clinical trials of the therapy, a combination of the drug Velcade and an experimental compound that was designed by researchers at the Broad Institute of Massachusetts...