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Latest Protective autoimmunity Stories

2009-11-03 13:57:40

Stem cells isolated from the brain of adult mice (adult neural stem cells [aNSCs]) have shown very modest therapeutic effects in a mouse model of the chronic inflammatory neurodegenerative disease multiple sclerosis. But now, Guang-Xian Zhang and colleagues, at Thomas Jefferson University, Philadelphia, have developed an approach to enhance the therapeutic effects of aNSCs in this model of multiple sclerosis. Specifically, the researchers genetically engineered aNSCs to express the...

2009-09-22 07:44:06

After spinal cord injury, certain immune cells collect in the spinal fluid and release high levels of antibodies. What, if anything, those antibodies do there is unknown. A new study by neuroscientists at The Ohio State University Medical Center may have solved the mystery. It found that the antibodies may actually worsen and extend the spinal cord damage. The antibodies first attach to nerve cells and other elements of the nervous system, then other components of the immune system attack the...

2009-09-22 07:39:23

Traumatic spinal cord injury causes permanent disability or loss of movement (paralysis) and sensation below the site of the injury. Currently, there are no treatments that can reverse the damage to the spinal cord, there are only approaches to prevent further damage and to help people return to an active lifestyle. However, Philip Popovich and colleagues, at the Ohio State University College of Medicine, Columbus, have studied the problem in mice and identified potential new therapeutic...

2009-09-08 14:49:21

Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research. "There are extremely precise mechanistic methods augmenting the ability of the immune system to distinguish between normal tissues and tumors," said lead researcher Richard G. Vile, Ph.D. "Understanding the multiple checks and safeguards against autoimmunity should...

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2009-09-01 13:10:00

Discovery that chemistry in zone between cells influences immune T-cell activity also has implications for cancer therapiesUniversity of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells. The findings open a new avenue of research for future therapies for conditions ranging from autoimmune diseases to organ transplants to cancer.The scientists discovered that the immune system's regulatory...

2009-07-20 10:26:53

Researchers from Helmholtz Center for Infection Research, Germany, decipher special role of the messenger Beta-interferon for immune responses Researchers from the Molecular Immunology group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now shown that Beta-Interferon also plays a crucial role during an immune response: without Beta-Interferon immune cells are unable to show "wanted posters" of pathogens to other cells. As a consequence, these cells will...

2009-06-11 07:54:07

Older mice are more susceptible to proteoglycan-induced arthritis (PGIA). Researchers writing in BioMed Central's open access journal Immunity & Ageing have shown, for the first time, that young mice are completely resistant, but become fully susceptible to the disease with age.Tibor Glant, from Rush University Medical Center, Chicago, worked with a team of researchers to investigate the effects of immunological senescence on susceptibility to arthritis. He said, "Our results suggest...

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2009-06-10 13:45:00

Over 100,000 people suffer from multiple sclerosis in Germany alone. Despite intensive research, the factors that trigger the disease and influence its progress remain unclear. Scientists from the Max Planck Institute of Neurobiology in Martinsried and an international research team have succeeded in attaining three important new insights into the disease. It would appear that B cells play an unexpected role in the spontaneous development of multiple sclerosis and that particularly aggressive...

2009-03-25 08:20:50

Current research describes a new method to track the development of autoimmune diseases before the onset of symptoms. The related report by Zangani et al, "Tracking early autoimmune disease by bioluminescent imaging of NF-ÃŽºB activation reveals pathology in multiple organ systems," appears in the April 2009 issue of The American Journal of Pathology.Autoimmune diseases such as lupus, multiple sclerosis, rheumatoid arthritis and diabetes are caused when the immune system...

2008-12-22 16:00:59

Potential autoimmunity-inducing cells have been found in healthy humans as well patients with autoimmune diseases such as lupus, U.S. researchers report. Whether these cells are precursors to the self-attacking cells prevalent in lupus and rheumatoid arthritis remains unknown, researchers lead by J. Andrew Duty at the Oklahoma Medical Research Foundation reported in a news release. As antibody-producing B cells develop in the bone marrow, the body tests them to determine whether they confuse...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'