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Latest Protein complexes Stories

2013-10-07 23:20:22

Reportbuyer.com just published a new market research report: Ubiquitin Proteasome: Global Markets for Research Tools, Diagnostics and Drug Discovery. London (PRWEB) October 07, 2013 STUDY GOALS AND OBJECTIVES This BCC Research report, Ubiquitin Proteasome: Global Markets for Research Tools, Diagnostics and Drug Discovery, provides an overview of the current overall state of ubiquitin proteasome market, focusing specifically on research tools, assay development, drug candidates and...

2013-04-26 14:11:20

Proteins, unlike diamonds, aren't forever. And when they wear out, they need to be degraded in the cell back into amino acids, where they will be recycled into new proteins. Researchers at Rockefeller University and the Howard Hughes Medical Institute have identified a new way that the cell's protein recycler, the proteasome, takes care of unwanted and potentially toxic proteins, a finding that has implications for treating muscle wasting, neurodegeneration and cancer. The consensus among...

2011-03-28 13:08:16

The discovery at Scripps Research could usher in a new way of designing non-toxic drugs, researchers say Over the last years, two teams of researchers at The Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions "“ findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis. In...

2009-12-21 14:31:54

The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, led by researchers from the University of California, Irvine, will be published online December 21 in the Journal of Cell Biology (www.jcb.org). Huntington's disease is caused by an expanded polyglutamine repeat in the protein Huntingtin (Htt), which causes the protein...

2009-10-02 09:14:48

Understanding how serious breaks in DNA are repaired may help researchers to make cancer therapy more effective Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy. The research was published in the October 2, 2009 issue of the journal Cell. This biological machine"”the Mre11-Rad50-Nbs1 (MRN)...

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2009-08-18 12:45:00

Cancer remains a deadly threat despite the best efforts of science. New hopes were raised a few years ago with the discovery that the uncontrolled growth of cancer cells could be thwarted by blocking the action of proteasomes. Biochemists at the Technische Universitaet Muenchen (TUM) have illuminated a reaction pathway that does just that, in collaboration with researchers from Nereus Pharmaceuticals, based in San Diego, California. In the current issue of the Journal of Medicinal Chemistry,...

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2009-08-05 09:20:00

As the body creates antibodies to fight invaders, a three-protein DNA repair complex called MRN is crucial for a normal gene-shuffling process to proceed properly, University of Michigan research shows.The discoveries in mice, published online this week in Nature Structural and Molecular Biology, advance understanding of the immune system and shed light on how B-cell lymphoma and some other cancers may begin.U-M scientists found that:When one protein in the MRN complex, Mre11, is absent,...

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2009-01-06 13:47:48

U-M scientists have identified a target that may predict tumors' sensitivity to radiation University of Michigan researchers have discovered that a key protein in cells plays a critical role in not one, but two processes affecting the development of cancer. "Most proteins involved in responding to DNA damage that can cause cancer either help detect the damage and warn the rest of the cell, or help repair the damage," says David O. Ferguson, M.D., Ph.D., the study's lead author. Ferguson is an...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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