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Latest Protein folding Stories

2013-02-27 23:00:06

The Protein Society, the leading international society devoted to furthering research and development in protein science, announces the winners of its 2013 Awards. The awards will be conferred at the 27th Annual Symposium of The Protein Society (July 20-23, 2013, Boston, MA, USA). Baltimore, Maryland (PRWEB) February 27, 2013 The Protein Society, the leading international society devoted to furthering research and development in protein science, announces the winners of its 2013 Awards. The...

2013-02-11 15:25:33

By combining low temperatures and NMR spectroscopy, the scientists visualized seven intermediate forms of the CylR2 protein while cooling it down from 25°C to -16°C. Their results show that the most instable intermediate form plays a key role in protein folding. The scientists' findings may contribute to a better understanding of how proteins adopt their structure and misfold during illness. Whether Alzheimer's, Parkinson's or Huntington's Chorea — all three diseases have one...

2012-11-01 10:13:42

Proteins are able to self-assemble into a wide range of highly ordered structures that feature a diverse array of properties. Through biomimicry — technological innovation inspired by nature — humans hope to emulate proteins and produce our own version of self-assembling molecules. A key to accomplishing this is understanding how protein-folding — a process critical to the form and function of a protein — is extended from individual proteins to complex assemblies....

2012-10-09 22:27:17

Neutrophil extracellular traps and amyloidosis aggravation Amyloidosis is a group of clinical syndromes characterized by deposits of amyloid fibrils throughout the body. These fibrils are formed by aggregates of proteins that have not been properly folded. Deposits of amyloid fibrils are found in a number of diseases, including Alzheimer's and Parkinson's diseases and type-2 diabetes. The amyloid deposits can be localized, as in the brain of Alzheimer's patients, or found spread through...

2012-07-23 20:52:59

A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals. U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain. "When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins...

Clearer Way To Treat Huntington's Disease Offered By 2 Proteins
2012-07-11 20:58:47

Pair helps remove and prevent misfolding of proteins that cause neurodegeneration In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of Huntington's disease (HD). The findings explain a fundamental aspect of how HD wreaks havoc...

Small Molecule Might Play Big Role In Alzheimer's Disease
2012-07-10 10:58:00

Simulations by UC Santa Barbara researchers improve understanding of plaque formation and suggest new diagnostic and treatment options Alzheimer's disease is one of the most dreaded and debilitating illnesses one can develop. Currently, the disease afflicts 6.5 million Americans and the Alzheimer's Association projects it to increase to between 11 and 16 million, or 1 in 85 people, by 2050. Cell death in the brain causes one to grow forgetful, confused and, eventually, catatonic....

2012-06-27 22:26:20

Long-term aim is to develop new treatments to block the spread of damaged proteins in the brain Van Andel Institute announces that researchers at Lund University in Sweden have published a study detailing how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells. This model has never before been identified so clearly in a living organism, and the...

2012-06-25 23:10:34

Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and...