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Latest Protein folding Stories

2011-04-27 14:31:00

Medical therapies may be developed to recover healthy proteins that are important to prevent diseases such as Alzheimer's disease and diabetes ANN ARBOR, Mich., April 27, 2011 /PRNewswire-USNewswire/ -- A computer analysis by two University of Michigan researchers shows promise for helping develop therapies for some major diseases by rescuing proteins that have stopped performing normally. Understanding the role of protein molecules is vital for health research and finding cures and...

2011-03-21 13:05:56

Romping clumps of misfolded proteins are prime suspects in many neurological disorders including Alzheimer's, Parkinson's, and Creutzfeld-Jakob Disease. Those diseases are devastating and incurable, but a team of biologists at Brown University reports that cells can fix the problems themselves with only a little bit of help. The insight suggests that there are more opportunities to develop a therapy for protein misfolding than scientists had thought. "There are multiple steps that you could...

2011-02-18 17:21:04

One bad apple is all it takes to spoil the barrel. And one misfolded protein may be all that's necessary to corrupt other proteins, forming large aggregations linked to several incurable neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's. Stanford biology Professor Ron Kopito has shown that the mutant, misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits. Knowing...

2011-02-09 01:05:18

The findings may enable scientists to better understand the molecular biology and biophysics of the brain and diseases such as Alzheimer's and Parkinson's A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque...

2011-01-07 18:47:37

A Jackson Laboratory research team led by Professor Patsy Nishina, Ph.D., has identified a mutation in a gene that's essential for correct protein-processing in cells. Defects in protein folding are associated with a variety of abnormalities and diseases. Cells don't come prefabricated, with pieces plunked down and tacked together like modular homes offloaded from trucks. The structural proteins that give cells shape, tubulin and actin (think beams and girders), are themselves subject to...

2010-10-28 23:03:53

Mad Cow disease and its human variant Creutzfeldt"”Jakob disease, which are incurable and fatal, have been on a welcome hiatus from the news for years, but because mammals remain as vulnerable as ever to infectious diseases caused by enigmatic proteins called prions, scientists have taken no respite of their own. In the Oct. 29 edition of the journal Science, researchers at Brown University report a key new insight into how prion proteins "” the infectious agents "” become...

2010-08-05 14:55:12

Biochemists and computer scientists at the University of Washington two years ago launched an ambitious project harnessing the brainpower of computer gamers to solve medical problems. The game, Foldit, turns one of the hardest problems in molecular biology into a game a bit reminiscent of Tetris. Thousands of people have now played a game that asks them to fold a protein rather than stack colored blocks or rescue a princess. Results published Thursday (Aug. 5) in the journal Nature show that...

2010-07-30 13:42:08

The apparently random self-assembly of molecular threads into the proteins that make the body work is far less frantic than previously thought, Michigan State University scientists say. That discovery could be a key to help unlock the nature of some diseases. How proteins spontaneously "fold" from wiggling chains of amino acids into a wide variety of functional "“ or malfunctioning "“ three-dimensional molecules is one of the biggest mysteries in biochemistry. "People thought they...

2010-07-07 15:48:03

New strategy boosts speed, accuracy in simulation of protein folding All proteins self-assemble in a fraction of the blink of an eye, but it can take a long time to mimic the process. And there has been no guarantee of success, even with the most powerful computers "“ until now. Rice University researchers have come up with a computer program to accurately simulate protein folding dramatically faster than previous methods. It will allow scientists to peer deeper into the roots of...

2010-06-18 01:55:35

Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate biological processes associated with diseases such as Alzheimer's and Parkinson's. Since proteins in the body perform different functions according to their shape, the folding process is considered a key area of study. Using a microfabricated fluid mixing device built at UCSB's...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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