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Latest Protein folding Stories

2010-06-18 01:27:53

Scientists watch as E. coli bacteria evolve heat resistance under stress Scientists in Munich report evidence that high concentrations of the molecular "chaperone" proteins GroEL and GroES -- intracellular machines that can stabilize folding proteins under stress -- play a critical role in increasing the maximum temperature at which E. coli bacteria can grow. Massively and permanently elevated levels of the GroE proteins were found in bacteria adapted, step-wise over a period of years, for...

2010-05-06 16:10:00

NEW YORK, May 6 /PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it has awarded a grant of $210,300 to Amicus Therapeutics (Nasdaq: FOLD; Cranbury, NJ) to evaluate small-molecule, orally delivered pharmacological chaperone compounds as a novel approach for treating Alzheimer's disease. Amicus has discovered an apparent link between various lysosomal enzymes and accumulation of the beta-amyloid and p-tau deposits observed in the brain of...

2010-03-15 16:06:12

Novel method distinguishes between structurally similar folding forms Researchers at the Department of Chemistry at the Technische Universität Mnchen (TUM) have developed a method that allows the observation of local movements in proteins on a time scale of nanoseconds to microseconds. Upon examining movements of the protein villin using this method they found two structures that were otherwise barely distinguishable from one another. Quick nanosecond-scale structure changes essential...

2010-01-20 13:14:32

Scientists at Duke University Medical Center have found some compounds that improve a cell's ability to properly "fold" proteins and could lead to promising drugs for degenerative nerve diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease. Misfolded proteins in nerve cells (neurons) are a common factor in all of these diseases. The Duke team has identified many new chemicals that activate a master regulator to increase the supply of "protein chaperone"...

2010-01-19 12:49:08

Single-molecule, real-time measurements of a key biological process Biophysicists at TUM, the Technische Universitaet Muenchen, have published the results of single-molecule experiments that bring a higher-resolution tool to the study of protein folding. How proteins arrive at the three-dimensional shapes that determine their essential functions "“ or cause grave diseases when folding goes wrong "“ is considered one of the most important and least understood questions in the...

2009-12-06 13:34:59

The dramatically new approach to protein misfolding could lead to new therapies for a number of diseases In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis. While there is still much work to be done before the therapy can be tested in humans, the discovery opens the door to a new class of therapies for this and a host of other chronic diseases. The results were...

2009-10-13 13:26:37

Researchers at Lund University have taken a snapshot of proteins changing shape, sticking together and creating structures that are believed to trigger deadly processes in the nervous system Researchers at Lund University, Sweden, have taken a snapshot of proteins changing shape, sticking together and creating structures that are believed to trigger deadly processes in the nervous system. The discovery opens the possibility of designing drugs for a devastating neurological disease, ALS....

2009-08-24 14:00:00

U.S. researchers say they've determined protein damage common in neurodegenerative and age-associated diseases might be treatable if detected early enough. Northwestern University medical scientists say misfolded and damaged proteins can be detected much earlier than has been thought possible, long before individuals exhibit symptoms. And if intervention occurs early enough damage could be delayed. The researchers said they studied seven different proteins of the worm C. elegans and found...

2009-08-06 15:04:18

 Rice University physicists have written the next chapter in an innovative approach for studying the forces that shape proteins -- the biochemical workhorses of all living things.New research featured on the cover of today's issue of the Journal of Physical Chemistry illustrates the value of studying proteins with a new method that uses the tools of nanotechnology to grab a single molecule and pull it apart. The new method helps scientists measure the forces that hold proteins together....

2009-07-29 13:22:19

Most parts of living organisms come packaged with ribbons. The ribbons are proteins"”chains of amino acids that must fold into three-dimensional structures to work properly. But when for any reason the ribbons fold incorrectly, bad things can happen, and in humans misfolded-protein disorders include Alzheimer's and Parkinson's diseases.Scientists have for the past three decades tried to understand what makes proteins fold into functional units and why it happens, and several...


Word of the Day
lambent
  • Licking.
  • Hence Running along or over a surface, as if in the act of licking; flowing over or along; lapping or bathing; softly bright; gleaming.
This word comes the Latin 'lambere,' to lick.
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