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Latest Protein folding Stories

2009-03-13 13:03:31

Imbalance of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster brains, according to a new study by Dr. Neena Singh and colleagues at Case Western Reserve University School of Medicine, alongside collaborators from Creighton University. These findings, published March 13 in the open-access journal PLoS Pathogens, provide new insight into the mechanism of neurotoxicity in prion disorders, and novel avenues for the development of therapeutic...

2009-03-03 08:25:25

Sometimes known as "nature's origami", the way that proteins fold is vital to ensuring they function correctly. But researchers at the University of Leeds have discovered this is a 'hit and miss' process, with proteins potentially folding wrongly many times before they form the correct structure for their intended purpose.The body's proteins carry out numerous functions and play a crucial role in the growth, repair and workings of cells. Sheena Radford, Professor of Structural Molecular...

2008-11-11 09:00:08

A recent study of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) has enabled a new understanding of the rare and fatal disease. The study explored the diagnosis, progression and mortality of the disease, and resulted in new insight into measures of disease progression as well as potential predictors of survival. Currently there is no available disease modifying pharmacologic therapy for ATTR-CM, and these significant strides in expanding the limited understanding of ATTR-CM will guide...

2008-10-07 09:00:14

FoldRx Pharmaceuticals, Inc. (FoldRx) today announced that enrollment is underway in an open-label Phase II clinical study with its lead drug candidate, Fx-1006A, for patients suffering from TTR Amyloid Cardiomyopathy (ATTR-CM). The company also announced progress in several other ongoing studies that are part of a larger development program evaluating its lead candidate. Fx-1006A is designed to stop the progression of TTR amyloidosis caused by the 'misfolding' of a protein called...

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2007-11-23 19:08:46

COLUMBUS , Ohio -- Scientists are one step closer to understanding how proteins move when they perform functions essential for supporting life. For the first time, scientists have directly observed how water lubricates the movements of protein molecules to enable different functions to happen. In a paper published in the online early edition of the Proceedings of the National Academy of Sciences, Ohio State University researchers report using ultra-fast light pulses to reveal how water...

2005-10-14 14:17:57

Proteins are chain molecules assembled from amino acids. The precise sequence of the twenty different types of amino acids in a protein chain is what determines which structure a protein folds into. The three-dimensional structures in turn specify the functions of proteins, which range from the transport of oxygen in our blood, to the conversion of energy in our muscles, and the strengthening of our hair. During evolution, the protein sequences encoded in our DNA have been optimised for these...

2005-07-11 22:40:00

(Santa Barbara, Calif.) - A ground-breaking new research approach to understanding the cellular processes of Alzheimer's and other degenerative diseases has revealed a promising pathway to the development of new types of drugs for these diseases. The discovery, made in the laboratory of Ratnesh Lal, research scientist in the Neuroscience Research Institute (NRI) at the University of California, Santa Barbara, is published in this week's online issue of the Proceedings of the National Academy...

2005-06-08 18:03:37

Howard Hughes Medical Institute researchers have provided the first detailed look at the core structure of the abnormal protein filaments found in at least 20 devastating diseases, ranging from Alzheimer's to Creutzfeldt-Jakob disease, the human version of "mad cow" disease. The images reveal that the filaments form a short zipper that is closed and stuck. To get a more realistic picture of what the fibrils look like, however, one should picture a towering stack of zippers, each of which is...