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Latest Protein kinases Stories

2014-06-30 23:19:26

The Life, Earth & Health Sciences Magazine has reorganized its structure to facilitate interaction with users. EurekaMag.com's new interface enables users to upload their science content for a new, private and spam-free web experience. Mannheim, Germany (PRWEB) June 30, 2014 EurekaMag.com has introduced a new structure and new approach to publishing science content. Due to many requests from its users, researchers can now upload their science content without sacrificing their...

2014-04-09 08:28:30

QUÉBEC CITY, April 9, 2014 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced that a poster on AEZS-134, a highly potent and selective ATP competitive Erk inhibitor, provides rationale for new therapeutic opportunities in oncology with this compound. The poster, titled, "Erk Inhibition as a Therapeutic Option for the Treatment of Raf- and Mek- Inhibitor Resistant Tumors", I. Seipelt, P. Schmidt, H. Märzhäuser, M. Gerlach, K. Jung, T....

2014-03-06 08:30:40

Initiates Phase 1 Trial for Intermittent Claudication SOUTH SAN FRANCISCO, Calif., March 6, 2014 /PRNewswire/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that the American Journal of Physiology has published recent research results with its orally-bioavailable AMPK activator, R118. The publication, entitled "Exercise performance and peripheral vascular insufficiency improve with AMPK activation...", provides strong preclinical evidence that R118 may be useful in...

2014-01-13 16:25:24

CINCINNATI, Jan. 13, 2014 /PRNewswire-USNewswire/ -- The diabetes drug metformin is also being tested in numerous clinical trials for treating different cancers, and several studies point to its apparent activation of a molecular regulator of cell metabolism called AMPK to suppress tumor growth. (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) But new research appearing the week of Jan. 13 in Proceedings of the National Academy of Sciences (PNAS) suggests that...

2014-01-07 14:18:21

Why inhibition of both pathways is important In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2. This reactivation of Akt limits quite efficiently the response of the tested tumor cell lines presenting constitutively active K-Ras activity (both through K-RAS mutation or...

2013-12-16 12:10:42

Research indicates e-cigarettes may not significantly reduce risk for heart disease Nicotine, the major addictive substance in cigarette smoke, contributes to smokers' higher risk of developing atherosclerosis, the primary cause of heart attacks, according to research to be presented Sunday, Dec. 15, at the American Society for Cell Biology Annual Meeting in New Orleans. These findings suggest that e-cigarettes, the battery-powered devices that deliver nicotine in steam without the...

Study Reveals Protein That Keeps People And Their Skeletons Organized
2013-11-14 10:34:42

University of Southern California Most people think that their planners or their iPhones keep them organized, when proteins such as liver kinase b1 (Lkb1) actually have a lot more to do with it. New research from postdoctoral fellow Lick Lai in the lab of USC scientist Andy McMahon published in Proceedings of the National Academy of Sciences (PNAS) sheds light on how this important protein keeps people organized on a basic level by promoting orderly skeletal growth and preventing skeletal...

2013-10-03 09:06:40

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered some key features that explain just what turns on a protein that is considered to be a master regulator of how the human body uses and stores energy. The new discoveries could help in the design and development of new therapeutics to treat metabolic disease such as diabetes and obesity—and perhaps some cancers as well. The new study, led by Patrick R. Griffin, chair of the TSRI Department of...

2013-08-13 11:35:26

Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and prolife-ration; however, the mechanism remains unclear. Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma. Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis. To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, Hua...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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