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Latest Protein kinases Stories

2012-01-24 10:43:55

Study of plant hormone could have far-reaching implications for cell biology and disease research A recent Van Andel Research Institute (VARI) study published in the journal Science investigating the molecular structure and function of an essential plant hormone could profoundly change our understanding of a key cell process, and might ultimately lead to the development of new drugs for a variety of diseases. The study builds on earlier work by the same team of investigators at VARI...

2011-11-07 11:44:27

MAP kinase resolved well enough to spot potentially unique drug target In many pharmaceutical company and university laboratories, scientists are looking closely at kinase complexes because the enzymes play key roles in essential cell functions. By taking unusual steps to examine a kinase complex, researchers at Brown University and the National Institutes of Health have found a sought-after prize: an unprecedentedly detailed description of its structure complete with a rare location...

2011-10-31 10:22:31

In a technical tour de force, scientists at Fox Chase Cancer Center have cataloged and cross-indexed the actions of 178 candidate drugs capable of blocking the activity of one or more of 300 enzymes, including enzymes critical for cancer and other diseases. Additionally, a free library of the results has been made available online to the research community. This unique library represents an important new tool for accelerating the development of an entire class of targeted cancer drugs. The...

2011-09-06 22:12:06

Study reveals that insulin-stimulated glucose uptake–a process that breaks down in type 2 diabetes–requires a previously unidentified protein called CDP138 All cells need glucose (sugar) to produce the energy they need to survive. High glucose levels in the bloodstream (such as occur after a meal), trigger the pancreas to produce insulin. In turn, muscle and fat cells respond to insulin by moving GLUT4, a glucose transporter, from intracellular storage out to the cell surface....

Missing Genes Could Turn You Into A Couch Potato
2011-09-06 04:49:33

  While some “couch potatoes” might attribute their lack of resolve to exercise to mere laziness, researchers have discovered these people may simply be missing some vital genes. The scientists at McMaster University made their unexpected finding while working with healthy, custom-bred mice, some of which had two muscle genes essential for exercise removed.  The genes control the protein AMP-activated protein kinase (AMPK), an enzyme that is switched on when you...

2011-07-18 15:42:53

A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology (www.jcb.org). The aggregation of mutant Huntingtin protein in HD disrupts many cellular processes, including metabolism. AMPK"”a protein that balances a cell's energy production and usage"”is abnormally active in the brains of mice with HD, but whether the kinase...

2011-06-03 12:36:50

Biotech scientists are working on novel protein kinase inhibitors that are targeting a host of conditions ranging from atherosclerosis to neurodegenerative diseases, reports Genetic Engineering & Biotechnology News (GEN). Recent developments in the protein kinase inhibitor field include innovative paradigms for drug development, improved inhibitor profiling and selectivity strategies, and the expansion of disease targets (e.g., Alzheimer disease and traumatic brain injury), according to...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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