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Latest Protein structure Stories

2009-10-02 08:54:45

Discovery could lead to treatments for learning and memory deficits, particularly Noonan's syndrome As most good students realize, repeated studying produces good memory. Those who study a lot realize, further, that what they learn tends to be preserved longer in memory if they space out learning sessions between rest intervals. Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have now discovered how this so-called "spacing effect" is controlled in the brain at the level of individual...

2009-09-23 07:50:49

The National Institute of Standards and Technology (NIST) has issued a new ruler, and even for an organization that routinely deals in superlatives, it sets some records. Designed to be the most accurate commercially available "meter stick" for the nano world, the new measuring tool"”a calibration standard for X-ray diffraction"”boasts uncertainties below a femtometer. That's 0.000 000 000 000 001 meter, or roughly the size of a neutron. The new ruler is in the form of a thin,...

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2009-09-17 09:45:31

UAB researchers discover that the separation of 2 or more proteins due to genetic mutations causes them to malfunction Researchers at the Department of Biochemistry and Molecular Biology of Universitat Autònoma de Barcelona (UAB) have revealed the process by which proteins with a tendency to cause conformational diseases such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc. finally end up causing them....

2009-09-13 12:41:26

Reveals shape-shifting atomic interactions; suggests mechanism and possible drug targets How much difference can a tenth of a nanometer make? When it comes to figuring out how proteins work, an improvement in resolution of that miniscule amount can mean the difference between seeing where atoms are and understanding how they interact. Case in point: New, improved-resolution views of a zinc transporter protein deciphered at the U.S. Department of Energy's Brookhaven National Laboratory provide...

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2009-08-21 08:35:00

What are the causes of illness? How can the effect of medication be improved? Molecular biologists can now gain new insights by the virtual simulations generated with a new type of software.If it's a question of the efficacy of vaccines or the aggressiveness of toxins, researchers must be able to simulate and analyze the molecules involved in three dimensions. What do they look like? What is the three-dimensional structure of a protein? How can this structure be used to predict which...

2009-08-20 13:48:47

U.S. scientists say they have discovered protein-shape changes affect drug binding. Computational biologists at the University of Pittsburgh School of Medicine have shown proteins have an intrinsic ability to change shape, and that allows small molecules that are attracted to a given protein to select the structure that permits the best binding. The researchers say that premise could help in drug discovery and in designing compounds that will have the most impact on protein function to better...

2009-08-06 15:04:18

 Rice University physicists have written the next chapter in an innovative approach for studying the forces that shape proteins -- the biochemical workhorses of all living things.New research featured on the cover of today's issue of the Journal of Physical Chemistry illustrates the value of studying proteins with a new method that uses the tools of nanotechnology to grab a single molecule and pull it apart. The new method helps scientists measure the forces that hold proteins together....

2009-07-29 13:22:19

Most parts of living organisms come packaged with ribbons. The ribbons are proteins"”chains of amino acids that must fold into three-dimensional structures to work properly. But when for any reason the ribbons fold incorrectly, bad things can happen, and in humans misfolded-protein disorders include Alzheimer's and Parkinson's diseases.Scientists have for the past three decades tried to understand what makes proteins fold into functional units and why it happens, and several...

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2009-07-21 09:39:42

Scientists at the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory have developed a fast and efficient way to determine the structure of proteins, shortening a process that often takes years into a matter of days. The high-throughput protein pipeline could allow scientists to expedite the development of biofuels, decipher how extremophiles thrive in conditions that kill most organisms, and better understand how proteins carry out life's vital functions. The technique...

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2009-06-25 14:10:00

In a landmark technical achievement, investigators in the Vanderbilt Center for Structural Biology have used nuclear magnetic resonance (NMR) methods to determine the structure of the largest membrane-spanning protein to date.Although NMR methods are routinely used to "take molecular pictures" of small proteins, large proteins "“ and particularly those that reside within the cell membrane "“ have been reluctant to smile for the camera.In the June 26 issue of Science, Charles...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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