Latest Protein structure Stories

2010-08-05 14:55:12

Biochemists and computer scientists at the University of Washington two years ago launched an ambitious project harnessing the brainpower of computer gamers to solve medical problems. The game, Foldit, turns one of the hardest problems in molecular biology into a game a bit reminiscent of Tetris. Thousands of people have now played a game that asks them to fold a protein rather than stack colored blocks or rescue a princess. Results published Thursday (Aug. 5) in the journal Nature show that...

2010-07-30 13:42:08

The apparently random self-assembly of molecular threads into the proteins that make the body work is far less frantic than previously thought, Michigan State University scientists say. That discovery could be a key to help unlock the nature of some diseases. How proteins spontaneously "fold" from wiggling chains of amino acids into a wide variety of functional "“ or malfunctioning "“ three-dimensional molecules is one of the biggest mysteries in biochemistry. "People thought they...

2010-07-07 15:48:03

New strategy boosts speed, accuracy in simulation of protein folding All proteins self-assemble in a fraction of the blink of an eye, but it can take a long time to mimic the process. And there has been no guarantee of success, even with the most powerful computers "“ until now. Rice University researchers have come up with a computer program to accurately simulate protein folding dramatically faster than previous methods. It will allow scientists to peer deeper into the roots of...

2010-05-17 08:04:25

Using the NSF-funded Ranger supercomputer at the Texas Advanced Computing Center, Pengyu Ren is working to develop faster, cheaper ways to search for new drugs Most drugs enter our bodies as small molecules, ligands that bind to the surface of target proteins, inhibiting their function and protecting our health. For a drug to tame a headache or reduce a swollen knee, the drug needs to be effective at small doses, and selective enough to limit side effects. With so many medicines to choose...

2010-05-04 13:08:59

Cryo-electron microscopy images shed light on virus structure, function UCLA researchers report in the April 30 edition of the journal Cell that they have imaged a virus structure at a resolution high enough to effectively "see" atoms, the first published instance of imaging biological complexes at such a resolution. The research team, led by Hong Zhou, UCLA professor of microbiology, immunology and molecular genetics, used cryo-electron microscopy to image the structure at 3.3 angstroms. An...

2010-04-08 11:38:37

Researchers at IRB Barcelona refine the process to obtain "photographs" of highly dynamic proteins, an important step in drug design. When designing a drug against a disease, chemists often used detailed plans of the proteins affected and against which the drugs must act. However, about a third of the proteins of our bodies have not yet been "photographed" because they generally vary in form, are in constant movements and have very little structure. This lack of "photographs" hinders the...

2010-04-01 08:33:39

Scientists at the University of Delaware have developed a new method for producing proteins critical to research on cancer, Alzheimer's, and other diseases. Developed by Zhihao Zhuang, UD assistant professor of chemistry and biochemistry, and his research group, the chemical method yields hundredsfold more ubiquitylated proteins than current approaches. Such proteins may hold the key to revealing such mysteries as how cancer cells gain resistance to cancer drugs. The advance is reported in...

2010-03-03 05:00:00

BOSTON and SAN DIEGO, March 3 /PRNewswire/ -- Stemgent, Inc., a biotechnology company based in San Diego, California, and Boston, Massachusetts, USA, announced today the formation of Ubiquigent Ltd, a new biotechnology company based in Dundee, Scotland. As part of the agreement, Stemgent will invest approximately $4.5 million (3 million pounds Sterling) in the new venture over the next three years. According to the terms of the agreement, Ubiquigent will produce biological products and...

2010-03-01 07:28:03

A new technique to study protein dynamics in living cells has been created by a team of University of Illinois scientists, and evidence yielded from the new method indicates that an in vivo environment strongly modulates a protein's stability and folding rate, according to research accepted for publication in the journal Nature Methods and posted on the journal's Web site Feb. 28. Martin Gruebele, the James R. Eiszner Professor of Chemistry at Illinois and corresponding author of the paper,...

2010-02-13 09:20:34

The National Center for Macromolecular Imaging at Baylor College of Medicine has received a five-year, $9.5 million award from the National Center for Research Resources, maintaining a record of more than 24 years of support to advance the development of research technology in the field of electron cryo-microscopy. NCRR, part of the National Institutes of Health, supports scientists and clinical researchers to advance critical technologies in structural biology, genomics, proteomics, imaging...

Word of the Day
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This word ultimately comes from the Medieval Latin 'cappa,' cloak.