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Latest Protein targeting Stories

2014-03-04 14:17:18

The enzyme PP1 has a key role in many of the body’s healthy functions and diseases. It’s so generally important that drug developers dare not target it. In a new study in the Proceedings of the National Academy of Sciences, Brown University scientists report a big leap in understanding how PP1 interacts with other proteins to behave specifically in distinct situations. That could lead to medicines that target it for precise benefits. In the Proceedings of the National Academy of...

2013-10-24 10:26:37

Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine (BUSM) and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made. These findings are published as a Letter in Nature (Park, E. et al. 2013)....

2013-10-10 23:04:12

The peroxisome, a tiny intracellular organelle, was discovered in the mid-1960s, and for nearly 50 years scientists were unsure of how it and TSC2 worked. Now a team at Texas A&M Health Science Center (TAMHSC) Institute of Biosciences and Technology (IBT) know that TSC2 keeps peroxisomes at the right levels to maintain healthy cells. Houston, TX (PRWEB) October 10, 2013 When it comes to survival on the cellular level, mysteries have abounded for decades. In a paper published in the...

2013-09-30 14:10:50

The outer membrane of bacteria contains many proteins that form tiny pores. They are important for absorbing nutrients and transmitting signals into the cell. The research group of Sebastian Hiller, Professor of Structural Biology at the Biozentrum, University of Basel, has now shown for the first time at atomic resolution, that these pore proteins are transported in an unstructured, constantly changing state to the outer bacterial membrane. This landmark study was recently published in the...

2013-07-08 12:09:26

UConn researchers shed new light on how cellular transport systems harness energy to perform their work inside the cell Using highly sensitive fluorescent probes, a team of scientists from the University of Connecticut has captured the never-before-seen structural dynamics of an important protein channel inside the cell's primary power plant – the mitochondrion. The UConn team's study found that the channel complex - known as the translocase of the inner mitochondrial...

2013-04-30 13:46:56

Scientists have devised a method for delivering tumor cell-killing enzymes in a way that protects the enzyme until it can do its work inside the cell. In their study in mBio®, the online open-access journal of the American Society for Microbiology, researchers assembled microscopic protein packages that can deliver an enzyme called PEIII to the insides of cells. By attaching a protein called ubiquitin to the enzyme, they were able to protect it from degradation by the cell, allowing the...

Algae Could One Day Help Fight Cancer
2012-12-10 15:08:04

[ Watch the Video: Biology Helping To Engineer Drugs ] Connie K. Ho for redOrbit.com — Your Universe Online Pond scum may be undervalued, but a team of scientists recently discovered it could have biological value. Researchers from the University of California, San Diego (UCSD) recently revealed that they have successfully genetically engineered algae that can make a complex, therapeutic drug that is anti-cancer. The researchers believe that the results of the experiment allow...

2012-10-19 01:44:17

Chemists at the California Institute of Technology (Caltech) have managed, for the first time, to simulate the biological function of a channel called the Sec translocon, which allows specific proteins to pass through membranes. The feat required bridging timescales from the realm of nanoseconds all the way up to full minutes, exceeding the scope of earlier simulation efforts by more than six orders of magnitude. The result is a detailed molecular understanding of how the translocon works....

2012-06-04 14:05:22

Census reveals unexpected variety of genes involved in cellular transport Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have conducted the first comprehensive census of human cells´ export workers. In a study published online today in Nature Cell Biology, they found an unexpected variety of genes involved in transporting molecules to the cell membrane and beyond. Using a combination of genetics and sophisticated microscopy, Rainer Pepperkok...

2012-04-18 09:20:01

Engineered particles tied to penetratin discover, deliver ligands for mitochondria, ribosomes Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles - called iPhage - to organelles inside the cell. In a paper published today online in Nature Communications, the team led by researchers at The University of Texas MD Anderson Cancer Center...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.