Quantcast

Latest Proteopathy Stories

2013-03-04 13:20:32

Proteins with mutations in 'prion-like' segments considered candidates for inherited forms of ALS, multisystem proteinopathy A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children's Research Hospital, and colleagues describe in an advanced online...

2013-02-12 20:24:47

Neuron have discovered an abnormal protein that first forms as a result of genetic abnormalities and later builds up in the brains of many patients with either disease. "In identifying the novel protein that abnormally accumulates in the brains of affected patients, we have uncovered a potentially new therapeutic target and biomarker that would allow clinicians to confirm diagnosis of the diseases," says senior author Dr. Leonard Petrucelli, Chair of Neuroscience at Mayo Clinic in Florida....

2012-06-25 23:10:34

Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and...

2012-06-20 11:13:47

Amyloid fibers in the brain are a hallmark of many neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments. These fibers result from aggregation of a specific protein in each disease–in Parkinson's, for example, the aggregated protein is called alpha-synuclein. Although amyloid fibers are implicated in numerous pathologies, they can also play beneficial, protective roles. In yeast, for example, they are associated with increased survival...

2012-03-24 04:41:53

An international team of researchers have developed a new method for measurement of aggregated beta-amyloid — a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer's disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid. Alzheimer's disease (AD) is the most common cause of memory decline and dementia. According to the Alzheimer World Report 2011, today around 36...

2011-05-02 19:38:29

A protein associated with Alzheimer's disease clogs several motors of the cell transport machinery critical for normal cell division, leading to defective neurons that may contribute to the memory-robbing disease, University of South Florida researchers report. In a new study published online in the journal Cell Cycle, scientists at the USF Health Byrd Alzheimer's Institute. the Florida Alzheimer's Disease Research Center, and Indiana University also suggest that the protein beta amyloid...

2011-04-27 14:31:00

Medical therapies may be developed to recover healthy proteins that are important to prevent diseases such as Alzheimer's disease and diabetes ANN ARBOR, Mich., April 27, 2011 /PRNewswire-USNewswire/ -- A computer analysis by two University of Michigan researchers shows promise for helping develop therapies for some major diseases by rescuing proteins that have stopped performing normally. Understanding the role of protein molecules is vital for health research and finding cures and...

2010-10-22 01:46:43

Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain. This is shown in a new study done by researchers at the Hertie Institute of Clinical Brain Research (HIH, University Hospital Tbingen, University of Tbingen) and the German Center for Neurodegenerative Diseases (DZNE), to be published...

2009-12-06 13:34:59

The dramatically new approach to protein misfolding could lead to new therapies for a number of diseases In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis. While there is still much work to be done before the therapy can be tested in humans, the discovery opens the door to a new class of therapies for this and a host of other chronic diseases. The results were...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
Related