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Latest Proteostasis Stories

Connection Among Protein Misfolding, Sleep Loss, And Age Strengthened By Fruit Fly Study
2014-02-21 13:16:54

University of Pennsylvania School of Medicine Pulling an "all-nighter" before a big test is practically a rite of passage in college. Usually, it's no problem: You stay up all night, take the test, and then crash, rapidly catching up on lost sleep. But as we age, sleep patterns change, and our ability to recoup lost sleep diminishes. Researchers at the Perelman School of Medicine, University of Pennsylvania, have been studying the molecular mechanisms underpinning sleep. Now they report...

2013-10-30 10:43:03

The National Institutes of Health (NIH) has chosen two leading aging researchers at Albert Einstein College of Medicine of Yeshiva University to chair panels at the first symposium on "geroscience"—the study of how aging influences the onset of chronic diseases. Aging is a major risk factor for major chronic diseases including cancer, cardiovascular disease and diabetes. Understanding the biological processes that underlie aging could lead to new ways of treating or even preventing...

For A Healthy Brain, Clear Out The Trash
2013-07-23 10:41:23

NIH/National Institute of Neurological Disorders and Stroke Recycling is not only good for the environment, it's good for the brain. A study using rat cells indicates that quickly clearing out defective proteins in the brain may prevent loss of brain cells. Results of a study in Nature Chemical Biology suggest that the speed at which damaged proteins are cleared from neurons may affect cell survival and may explain why some cells are targeted for death in neurodegenerative disorders....

2008-08-26 12:01:27

Proteostasis Therapeutics has secured $45 million in a series A financing to develop Proteostasis Regulator drugs as novel therapies to treat multiple genetic and degenerative disorders associated with protein homeostasis deficiencies. Investors included HealthCare Ventures, Fidelity Biosciences, New Enterprise Associates, Novartis Option Fund and Genzyme Ventures. Christopher Mirabelli, chairman of the board of Proteostasis, said: "The significant series A round is designed to support...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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