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Latest PTEN Stories

2013-05-21 21:07:01

Researchers from the Masonic Cancer Center, University of Minnesota, and the University´s Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer. The research was published this week in the journal Nature Genetics. Utilizing the Sleeping Beauty transposon method, researchers in the lab of David Largaespada, Ph.D., professor in the Medical School and...

2013-02-25 13:38:04

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumor-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumor process, make the cancer tumor more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs....

2013-02-25 10:45:11

Scripps Research Institute team shows how DNA sequences long considered 'junk' are involved in gene regulation Small stretches of DNA in the human genome are known as "pseudogenes" because, while their sequences are nearly identical to those of various genes, they have long been thought to be non-coding "junk" DNA. But now, a new study led by scientists at The Scripps Research Institute (TSRI) shows how pseudogenes can regulate the activity of a cancer-related gene called PTEN. The...

A Rewired Serotonin System May Help Medications Be More Effective With Fewer Side Effects
2013-02-15 14:47:11

Lee Rannals for redOrbit.com — Your Universe Online One new method may be able to lead to more effective medications, with fewer side effects, according to research published in the Journal of Neuroscience. Scientists from the University of Texas Medical Branch (UTMB) at Galveston and the University of Houston found a new way to influence the vital serotonin signaling system. The team linked malfunctions in serotonin signaling to a range of health issues, including everything from...

2012-11-29 14:32:03

The combined loss of two tumor suppressor genes, retinoblastoma (RB) and phosphatase and tensin homolog (PTEN) was shown to be strongly associated with progression of DCIS to invasive breast cancer, according to a study published November 28 in the Journal of the National Cancer Institute. Ductal carcinoma in situ (DCIS) is a breast cancer precursor lesion for which there are no established markers defining risk of progression to invasive breast cancer. As a result, the majority of...

IFV Treatment Gets Boost From Being Inhibited
2012-09-25 05:12:42

Connie K. Ho for redOrbit.com — Your Universe Online “I'm thirty-seven and I want a baby.” Kate Holbrook, played by comedian Tina Fey, is a modern woman who wants it all — career, family, happiness. In order to achieve all this and more, she seeks a surrogate who could help her give birth. Movies like “Baby Mama” are just a few of the films that examine in vitro fertilization (IVF) and, on the science side, many research studies have examined the process...

2012-08-13 11:10:54

Scientists affiliated with the UC Davis MIND Institute have discovered how a defective gene causes brain changes that lead to the atypical social behavior characteristic of autism. The research offers a potential target for drugs to treat the condition. Earlier research already has shown that the gene is defective in children with autism, but its effect on neurons in the brain was not known. The new studies in mice show that abnormal action of just this one gene disrupted energy use in...

2012-05-09 21:16:34

Whole-genome sequencing of 25 tumors confirms role of sun damage while revealing new genetic alterations Melanoma — the deadliest and most aggressive form of skin cancer — has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced the whole genomes of 25 metastatic melanoma tumors, confirming the role of chronic sun exposure and revealing new genetic changes important in tumor formation....

2012-04-16 23:30:52

A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16th in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules. Many cancers are associated with the loss of function of...

2012-03-08 06:12:15

(Ivanhoe Newswire) — We dream of a world where we can eat whatever we like and not worry about the consequences, like weight gain and health issues, and now we might be a step closer. A new study shows mice with an extra dose of a known anti-cancer gene lose weight even as their appetites grow and also live longer. In a case study, researchers studied a tumor suppressor commonly lost in human cancers. Mice were given an extra dose of a known anti-cancer gene, known as Pten. Not only...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.