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Latest PTEN Stories

2011-08-05 12:52:01

New research from a team including several Carnegie scientists demonstrates that a specific small segment of RNA could play a key role in the growth of a type of malignant childhood eye tumor called retinoblastoma. The tumor is associated with mutations of a protein called Rb, or retinoblastoma protein. Dysfunctional Rb is also involved with other types of cancers, including lung, brain, breast and bone. Their work, which will be the cover story of the August 15th issue of Genes &...

2011-07-26 21:11:54

Scientists believe they have identified a role for PTEN, a known tumor suppressor, in removing DNA damage derived from UVB radiation, a known risk factor for non-melanoma skin cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. Yu-Ying He, Ph.D., an assistant professor of medicine at the University of Chicago, found that laboratory mice with reduced levels of PTEN were more likely to have UVB-induced skin cancers. "This was an...

2011-06-14 23:22:26

Cancer is crafty. When one avenue driving its growth is blocked by drugs targeting that path, the malignancy often creates a detour, finding an alternative route to get around the roadblock. In a study at UCLA's Jonsson Comprehensive Cancer Center, researchers found that when a common type of prostate cancer was treated with conventional hormone ablation therapy blocking androgen production or androgen receptor (AR) function"“ which drives growth of the tumor "“ the cancer was...

2011-06-07 22:18:11

U.S. Department of Agriculture (USDA)-funded studies of mammary gland development in laboratory rats fed blueberries or other foods of interest may aid breast cancer research. In an early study that has paved the way to follow-up experiments, Rosalia C. M. Simmen of the Arkansas Children's Nutrition Center (ACNC) in Little Rock, Ark., has determined that several indicators of rat mammary gland health were improved in the offspring (pups) of mothers (dams) that had been fed 5 percent blueberry...

2011-06-06 14:59:19

A mutant gene long thought to accelerate tumor growth in thyroid cancer patients actually inhibits the spread of malignant cells, showing promise for novel cancer therapies, a Mayo Clinic study has found. The findings will be presented by Mayo Clinic researcher Honey Reddi, Ph.D., at the Endocrine Society meeting in Boston. Dr. Reddi's discovery could have widespread implications in cancer research and endocrinology. It could help oncologists sharpen the diagnosis of specific types of thyroid...

2011-06-06 12:52:41

ASCO Abstract #10504. Contrary to what many oncologists had thought, a tumor suppressor protein known as PTEN does not reduce the effectiveness of the breast cancer drug Herceptin, according to a study by Mayo Clinic and North Central Cancer Research Group (NCCTG) investigators. The study, which looked at tumors from 1,802 patients enrolled in the NCCTG N9831 clinical trial, found that patients with HER2-positive breast cancer and had either a loss of PTEN functioning or normal PTEN activity...

2011-06-06 08:00:10

(Ivanhoe Newswire) -- Mayo Clinic researchers have found a mutant gene, which was long thought to accelerate tumor growth in thyroid cancer patients, actually inhibits the spread of cancerous cells. Thyroid cancer is the sixth most common cancer in the world. Between 15 percent and 20 percent of all thyroid cancers are follicular, which is a type that is more aggressive. Distinguishing between benign and malignant follicular thyroid cancer is often challenging for doctors because an accurate...

2011-05-13 07:48:11

(Ivanhoe Newswire) "“ Prostate cancer affects many men nationwide, and if caught early enough is curable, but little is understood about the mechanisms that cause a tumor to metastasize and spread to other parts of the body. Protein plays one of the "Ëœbad guy' roles in this process, according to this study. "This research could serve a diagnostic purpose in terms of likelihood of whether prostate cancers at early stages will progress into metastatic tumours," Damu Tang, an...

2011-05-03 22:49:54

UT MD Anderson-led team finds evidence that WWP2 subverts a brake on cell growth A protein known as WWP2 appears to play a key role in tumor survival, a research team headed by a scientist at The University of Texas MD Anderson Cancer Center reports in an advance online publication of Nature Cell Biology. Their research suggests that the little-studied protein binds to the tumor-suppressing protein PTEN (phosphatase and tensin homologue deleted on chromosome 10), marking it for destruction by...

2011-03-14 16:21:26

St. Jude Children's Research Hospital investigators use a novel model system to show how specific mutations can induce glioma formation in multiple regions of the brain and to begin studying patient response to a new generation of targeted therapies Mutations in three pathways important for suppressing tumors cooperate to launch glioblastoma, an aggressive brain tumor that strikes children and adults. But new research from St. Jude Children's Research Hospital scientists shows those changes...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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