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Latest PTEN Stories

2011-03-14 14:00:12

UT MD Anderson scientists find adding SRC inhibitor breaks hub of opposition Breast cancer tumors take numerous paths to resist the targeted drug Herceptin, but a single roadblock at a crucial crossroads may restore a tumor's vulnerability to treatment, scientists at The University of Texas MD Anderson Cancer Center report on line at Nature Medicine. Adding the drug saracatinib to Herceptin treatment shrinks previously resistant tumors by cutting off at least five different molecular...

2011-03-09 15:49:38

CSF holds potential clues to brain tumors Cerebrospinal fluid (CSF), the fluid found in and around the brain and spinal cord, may play a larger role in the developing brain than previously thought, according to researchers at Children's Hospital Boston. A paper published online March 10th by the journal Neuron sheds light on how signals from the CSF help drive neural development. The paper also identifies a CSF protein whose levels are elevated in patients with glioblastoma, a common...

2011-03-01 08:00:00

JAMAICA PLAIN, Mass., March 1, 2011 /PRNewswire/ -- Paloma Pharmaceuticals, Inc. announced today updates on its age-related macular degeneration Phase I trials and oncology program. Palomid 529 (P529), Paloma Pharmaceuticals first-in-class allosteric dual TORC1/TORC2 dissociative inhibitor targeting the PI3K/Akt/mTOR pathway, has successfully completed the Company's first three cohorts of its Phase I intravitreal administration trial in patients with age-related macular degeneration...

2011-02-02 20:27:46

Finding lays the groundwork for gene-based test Prostate tumors that carry a "signature" of four molecular markers have the potential to become dangerously metastatic if not treated aggressively, researchers at Dana-Farber Cancer Institute report in a study published online today by the journal Nature. The discovery lays the groundwork for the first gene-based test for determining whether a man's prostate cancer is likely to remain dormant within the prostate gland, or spread lethally to...

2011-01-10 14:04:38

Large study offers more accurate diagnosis, guide to genetic testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers. The research has created a diagnostic scoring system that improves on established criteria. Led by Charis Eng, M.D., Ph.D., Chair of the Genomic Medicine Institute at the Lerner...

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2010-12-14 08:41:26

When the best therapies fail, drug combos offer new hope This past summer saw a revolution in melanoma therapy. Patients whose melanoma lesions contain a mutation in the BRAF gene were successfully treated with a BRAF-specific inhibitor, PLX4032. Reports of the drug trial described shrinking tumors and improved health. Yet seven months after therapy began the tumors returned and resumed growing. Now, scientists at The Wistar Institute explain why: the tumor learns to signal around the blocked...

2010-12-02 21:52:09

Findings could result in the development of new drugs to fight cancer A protein that is crucial for regulating the self-renewal of normal prostate stem cells, needed to repair injured cells or restore normal cells killed by hormone withdrawal therapy for cancer, also aids the transformation of healthy cells into prostate cancer cells, researchers at UCLA have found. The findings, by researchers with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, may...

2010-08-09 14:55:03

Researchers explain how a facultative enzyme governs tumor growth Inhibiting prostate cancer without disturbing regular body processes Researchers explain how a facultative enzyme governs tumour growth A kinase is a type of enzyme the body uses to regulate the functions of the proteins required for cell growth and maintenance, and researchers have discovered that one in particular plays a key role in developing prostate cancer. "It's known as Mnk, and although it appears not to be essential...

2010-08-09 14:08:48

Researchers from UCI, UCSD and Harvard deleted a cell growth inhibitor called PTEN Researchers for the first time have induced robust regeneration of nerve connections that control voluntary movement after spinal cord injury, showing the potential for new therapeutic approaches to paralysis and other motor function impairments. In a study on rodents, the UC Irvine, UC San Diego and Harvard University team achieved this breakthrough by turning back the developmental clock in a molecular...

2010-07-13 15:10:04

Light has been cast on the interaction between broccoli consumption and reduced prostate cancer risk. Researchers writing in BioMed Central's open access journal Molecular Cancer have found that sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing. Richard Mithen, from the Institute of Food Research, an institute of BBSRC, worked with a team of researchers on Norwich Research Park, UK, to carry out a...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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