Latest PTEN Stories

Researchers at UCLA's Jonsson Comprehensive Cancer Center showed for the first time that the loss or decreased expression of the tumor suppressor gene PTEN plays a central role in the malignant transformation of benign nerve tumors called neurofibromas into a malignant and extremely deadly form of sarcoma.The work, a collaboration between the Institute for Molecular Medicine, the Department of Molecular and Medical Pharmacology and the cancer center's Sarcoma Program, could lead to the...

FORT ATKINSON, Wis., Oct. 8 /PRNewswire/ -- Professional Tool & Equipment News (PTEN), the only publication that exclusively serves the tool and equipment market, announces the PTEN 2009 Innovation Award Winners. Winners were selected by a panel of active technicians, shop owners and tool distributors who rated products used in their repair shops according to innovation, problem solving, ease of use, uniqueness to a specific repair, and whether it improved on a current tool. "These...

CHICAGO, July 6 /PRNewswire/ -- Today's "Sidewinder: Option Volume V. Open Interest" video, hosted by www.ONN.tv 's Chief Investment Strategist Jud Pyle, covers notable options trading activity from: Patterson-UTI Energy Inc. (PTEN) Noble Corp. (NE) (Logo: http://www.newscom.com/cgi-bin/prnh/20090323/AQM046LOGO) Recorded live from downtown Chicago, the Sidewinder Report is a daily look at notable options activity and unusual price action. This video can be found on www.ONN.tv in the...

 A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast cancer stem cells.Further, by using a drug that interferes with that pathway, the researchers produced an up to 90 percent decrease in the number of cancer stem cells within a tumor. The study appears in the June...

Cancer develops when cells known as cancer stem cells begin to divide in an uncontrolled manner. Researchers from the University of Michigan Comprehensive Cancer Center have identified roles for the gene PTEN, which is already well known for its ability to suppress tumor growth, and for several pathways linked to PTEN in the growth of cells that give rise to breast cancer. The work, published in this week's issue of the open-access journal PLoS Biology, also reports that a drug that...

Scientists know a protein gene called PTEN is a major tumor-suppressor. When it's reduced or mutated, cancers can grow.Researchers from the University of Texas M.D. Anderson Cancer Center have discovered a second gene that appears to protect PTEN, a finding that could one day lead to new treatments for cancers of the breast and other organs.The new gene is called Rak, and it works to stabilize PTEN by attaching a phosphate group to the protein, thus blocking an enzyme that leads to its...

A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. The discovery was made using a new research model, using mice, which replicates many aspects of human bladder cancer. The model also enabled the researchers to demonstrate that two major tumor suppressor genes, p53 and PTEN, are inactivated in invasive bladder cancer. The findings and this new model are described in a paper in the March...

Discovery could lead to drugs targeting gene interactionsBy pinpointing two genes that cause autism-like symptoms in mice, researchers at MIT's Picower Institute for Learning and Memory have shown for the first time that multiple, interacting genetic risk factors may influence the severity of autistic symptoms.The study, reported in the Feb. 9 advance online edition of the Proceedings of the National Academy of Sciences (PNAS), lends support to researchers' long-suspected belief that in...

When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.This phenomenon of delinquency puzzled scientists for a long time "” until a cell biologist in the Johns Hopkins University School of Medicine felt compelled to genetically grab the protein by the tail and then watched as it got back...

A U.S. study shows a key genetic pathway for cell growth and division is similar in both humans and flatworms, or planarians. Planarians, normally living in freshwater, are known for their ability to regenerate. A planarian cut into 200 pieces can generate 200 new individuals. Now research suggests the planarian can help scientists understand the basis of human development and disease. Scientists at the University of Utah and the Forsyth Institute at Harvard University report planaria...