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Latest Pyrazines Stories

2008-07-28 15:01:01

Velcade is likely to receive EMEA approval following a positive opinion issued by the EU Committee for Medicinal Products for Human Use for use in previously untreated multiple myeloma patients. Velcade would see considerable uptake if the drug is approved in the first-line setting, due to its proven activity and favorable safety profile compared to current treatment regimens. Velcade (bortezomib; Takeda/Johnson & Johnson) has received a positive opinion from the EU Committee for...

2008-07-28 09:01:47

CAMBRIDGE, Mass., July 28 /PRNewswire/ -- Millennium: The Takeda Oncology Company today announced the initiation of a Phase I trial series of MLN4924, the Company's first-in-class, small molecule inhibitor of the Millennium-discovered target, the Nedd 8 Activating Enzyme (NAE). MLN4924 advanced to the clinic with the first patient dosed in April 2008. The two Phase I dose escalation studies aim to assess safety, tolerability, pharmacokinetic and pharmacodynamic effects in patients with...

2008-07-09 12:00:49

WASHINGTON, July 9 /PRNewswire-USNewswire/ -- In a congressional hearing Secretary of Veterans Affairs James B. Peake, M.D., discussed the safety and importance of the research programs operated by the Department of Veterans Affairs (VA) as well as an absolute commitment to its patients, while expressing regret that even a single veteran would feel improperly treated or misused. "VA has an outstanding research program, and has been innovative in its protection of human research subjects,"...

2006-08-15 07:20:00

NEW YORK -- Varenicline, a non-nicotine drug designed specifically for smoking cessation, appears to be safe and effective according to a study in the Archives of Internal Medicine. Varenicline is FDA-approved and marketed by Pfizer as Chantix. It binds to a nicotine receptor that's believed to trigger the rewarding effects felt with smoking. Because varenicline competes more strongly than nicotine to bind to the receptor, yet has less of a rewarding effect, the investigators figured that it...

2006-07-04 15:50:00

By Anthony J. Brown, MD NEW YORK -- Treatment with a new drug called varenicline (Chantix) may be more effective than bupropion (Zyban) in helping smokers kick the habit, and it may also promote longer-lasting abstinence, suggest results of three studies in the Journal of the American Medical Association this week. However, according to a related editorial, the drug is no panacea for people wishing to quit smoking. "There are some important gastrointestinal side effects and, in the current...

2006-06-27 16:20:00

NEW YORK (Reuters Health) - Cognitive behavioral therapy (CBT), a counseling method that emphasizes the role of thinking and behavior modification, is more effective than zopiclone for the short- and long-term treatment of chronic insomnia in older adults, according to a new report. In fact, the study found that zopiclone was no more effect for insomnia than placebo was (a sugar pill.) Zopiclone, sold under the trade name Imovane, is a central nervous system depressant. To prevent excessive...

2006-05-11 15:16:57

By Lisa Richwine WASHINGTON (Reuters) - U.S. health regulators on Thursday approved a smoking cessation pill by Pfizer Inc. that helped about one-fifth of cigarette smokers quit the habit for a year in trials. The prescription drug, Chantix, is one of several medicines the world's largest drug maker is counting on to restore earnings growth. Pfizer has forecast annual Chantix sales of $1.2 billion by 2010, but some analysts are skeptical. Chantix works differently than older...

2006-05-11 08:55:00

WASHINGTON (Reuters) - The U.S. Food and Drug Administration said on Thursday it approved Pfizer's Chantix tablet to help cigarette smokers stop smoking. The active ingredient in Chantix, varenicline tartrate, acts at sites in the brain affected by nicotine, the FDA said. The drug may help smokers trying to kick the habit by providing some nicotine effects to ease the withdrawal symptoms, and by blocking the effects of nicotine from cigarettes if they resume smoking, the agency said. Chantix...

2006-03-15 00:55:00

By Kim Dixon CHICAGO -- Strange behavior by insomniacs taking prescription drugs, ranging from binge eating to having sex while asleep, have raised safety questions about anti-insomnia medications like Sanofi-Aventis' Ambien. Researchers in Minnesota are studying cases where insomniacs taking Ambien got up in the middle of the night, binged uncontrollably, then remembered nothing of their actions. The researchers expect to publish data shortly. Such sleep-induced side effects while on the...

2005-12-21 14:09:19

NEW YORK (Reuters) - Pfizer Inc. said on Wednesday that U.S. regulators have granted a priority review to its experimental smoking cessation drug. Under a priority review, the U.S. Food and Drug Administration will make its decision on whether or not to approve the drug within six months, rather than the usual 10- to 12-month review period. The world's largest drugmaker said it plans to market the drug, varenicline tartrate, under the brand name Champix if it is approved.


Word of the Day
toccata
  • In music, a work for a keyboard-instrument, like the pianoforte or organ, originally intended to utilize and display varieties of touch: but the term has been extended so as to include many irregular works, similar to the prelude, the fantasia, and the improvisation.
This word is Italian in origin, coming from the feminine past participle of 'toccare,' to touch.
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