Latest Pyrimidine dimers Stories

Mechanism of UV-induced DNA Dewar lesion revealed Excessive exposure to ultraviolet (UV) radiation of sunlight can result in skin damage and may even induce skin cancers. Irradiation with UV light causes mutations in the DNA, which can interfere with or even inhibit the read-out of genetic information and hence affect the cell function. The Dewar lesion is one of the major UV-induced reaction products, which can itself generate mutations. Understanding the mechanism that leads to the...

Researchers who have been working for nearly a decade to piece together the process by which an enzyme repairs sun-damaged DNA have finally witnessed the entire process in full detail in the laboratory.What they saw contradicts fundamental notions of how key biological molecules break up during the repair of sunburn "“ and that knowledge could someday lead to drugs or even lotions that could heal sunburn in humans.In the Proceedings of the National Academy of Sciences (PNAS), the Ohio State...