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Latest Pyruvate kinase Stories

2012-11-27 13:06:13

PKM2 slips into nucleus to promote cancer; potential biomarker and drug approach discovered Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which brain tumors thrive. They also found a vital spot along the protein's journey that can be attacked with a type of drug not yet deployed against glioblastoma multiforme, the...

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2012-08-27 21:11:44

Lee Rannals for redOrbit.com — Your Universe Online Boosting the activity of a particular enzyme can help block tumors from growing, according to research published in Nature Chemical Biology. Cancer cells use up most of their energy by reproducing themselves, but in order to do this they must produce new cellular building blocks like DNA, carbohydrates and lipids. Biologists found that jacking up the activity of the enzyme pyruvate kinase can disrupt the production of tumors...

2010-09-16 20:59:29

Cancer-cell quirk could be exploited to develop new drugs that starve tumors In a paper appearing in the Sept. 16 online edition of Science, Matthew Vander Heiden assistant professor of biology and member of the David H. Koch Institute for Integrative Cancer Research at MIT and researchers at Harvard University report a previously unknown element of cancer cells' peculiar metabolism. They found that cells can trigger an alternative biochemical pathway that speeds up their metabolism and...

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2010-06-17 08:28:31

University of Michigan and NIH scientists find a biological mechanism to explain the phenomenon During pregnancy, many women experience remission of autoimmune diseases like multiple sclerosis and uveitis. Now, scientists have described a biological mechanism responsible for changes in the immune system that helps to explain the remission. The expression of an enzyme known as pyruvate kinase is reduced in immune cells in pregnant women compared to non-pregnant women, according to Howard R....


Word of the Day
toccata
  • In music, a work for a keyboard-instrument, like the pianoforte or organ, originally intended to utilize and display varieties of touch: but the term has been extended so as to include many irregular works, similar to the prelude, the fantasia, and the improvisation.
This word is Italian in origin, coming from the feminine past participle of 'toccare,' to touch.
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