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UT MD Anderson scientists find new biomarkers for erlotinib treatmentTwo sets of gene expression profiles predict response to a common lung cancer drug for patients that have no guiding indicators for their treatment now, scientists from The University of Texas MD Anderson Cancer Center report at the AACR 102nd Annual Meeting."The only way we have to predict erlotinib's treatment benefit for patients now is by checking for certain mutations and amplifications of the epidermal growth...

Repeat biopsies may provide information critical to guiding treatment decisionsA detailed analysis of lung tumors that became resistant to targeted therapy drugs has revealed two previously unreported resistance mechanisms. In a report in the March 23 Science Translational Medicine, investigators from the Massachusetts General Hospital (MGH) Cancer Center also describe how the cellular nature of some tumors actually changes in response to treatment and find that resistance-conferring...

LSU oncologist Vince D. Cataldo, MD, is the lead author of a review article reporting two chemotherapy drugs now indicated for second and third-line therapy in patients with advanced non-small-cell lung cancer are remarkably effective in treating a certain subset of these patients. Dr. Cataldo, a Clinical Assistant Professor of Medicine at LSU Health Sciences Center New Orleans School of Medicine, practicing at LSU's Earl K. Long Medical Center and Hematology-Oncology Clinic in Baton Rouge,...

European Multidisciplinary Conference in Thoracic Oncology newsThe targeted cancer drug erlotinib has comparable efficacy to chemotherapy, and is better tolerated, in hard-to-treat cases where a patient's cancer has progressed quickly after treatment with first-line therapy, the results of a new phase III trial show.Dr Tudor Ciuleanu from the Institute of Oncology Ion Chiricuta, Cluj-Napoca, Romania, reported this finding from the international TITAN study at the European Multidisciplinary...

European Multidisciplinary Conference in Thoracic Oncology newsSpanish researchers have identified a gene whose expression level strongly predicts how well certain lung cancer patients will respond to treatment with the drug erlotinib.Dr Rafael Rosell and colleagues reported their findings at the European Multidisciplinary Conference in Thoracic Oncology (EMCTO), 24-26 February 2011 in Lugano, Switzerland.The researchers studied 55 patients with non-small cell lung cancer, whose tumors had...

SAN DIEGO, Feb. 22, 2011 /PRNewswire/ -- Proacta Incorporated and Yakult Honsha Co., Ltd. (Tokyo: 2267) today announced the execution of a definitive agreement relating to the collaborative research, development and commercialization of Proacta's PR509, a hypoxia-activated pro-drug for the treatment of cancer. (Logo: http://photos.prnewswire.com/prnh/20110222/LA50556LOGO-a ) (Logo: http://photos.prnewswire.com/prnh/20110222/LA50556LOGO-b ) "We have worked diligently to arrive at this...

WALTHAM, Mass., Jan. 4, 2011 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, today announced that Joanna Horobin, M.D., the company's president and CEO, will present at the Biotech Showcase 2011 on Tuesday, January 11, 2011 at 10:00 a.m. PT at the Parc 55 Wyndham hotel in San Francisco. Dr. Horobin's presentation will include the recently reported results from a randomized phase 2 study, which showed a four-month survival advantage when...

University of Colorado-developed treatment effective in Phase 2 Trials in a biomarker-selected group of patientsA combination therapy for treating cancer discovered at the University of Colorado Cancer Center showed improved survival rates in patients with advanced non-small cell lung cancer (NSCLC), according to results presented today from a double-blind, placebo-controlled phase 2 trial run by Syndax Pharmaceuticals. The phase 2 results show that the combination of entinostat (Syndax's...

(IVANHOE NEWSWIRE)-- Combining epigenetic therapy and molecular targeted therapy has shown promising results for combating advanced lung cancer.Epigenetic therapy is designed to control the expression of good and bad genes that influence the development of resistance to targeted therapies. This study, called ENCORE 401, evaluates whether entinostat, a novel epigenetic therapy that is given orally, can be used to delay or overcome the resistance to erlotinib, a drug used to treat patients with...

A new study shows that a combination of epigenetic therapy and molecular targeted therapy has promising results at combating advanced lung cancer according to research presented at the 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is co-sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO), the International Association for the Study of Lung Cancer (ISLAC) and The University of Chicago.Epigenetics...