Latest RANKL Stories
New research in animals triggered by a combination of serendipity and counterintuitive thinking could point the way to treating fractures caused by rapid bone loss in people, including patients with metastatic cancers.
Stress can promote breast cancer cell colonization of bone.
Investigators from the Vanderbilt Center for Bone Biology have discovered that stress can promote the colonization of breast cancer cells in bone.
Scientists have found a master regulator gene needed for the development of M cells, a mysterious type of intestinal cell involved in initiating immune responses.
When doctors discover high concentrations of regulatory T cells in the tumors of breast cancer patients, the prognosis is often grim, though why exactly has long been unclear.
THOUSAND OAKS, Calif., April 19 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN) today announced results of a preclinical study demonstrating a positive response to administration of RANK-Fc against mammary tumor formation in mouse models. OPG-Fc and RANK-Fc bind to and block the action of RANKL.
The mammalian system for controlling bone remodelling also regulates fever.
Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints.
In blood cells, the protein Bcl-xL has a well-characterized role in preventing cell death by a process known as apoptosis.
U.S. researchers say immune system-based approaches may help in treating osteoporosis. The study, published in Clinical Immunology, links bone loss to the immune system's reaction to cholesterol-related oxidation -- cell and tissue damage from exposure to free radicals.
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