Quantcast
Last updated on April 24, 2014 at 14:25 EDT

Latest Raymond C. Stevens Stories

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

3D Structure Of Key Drug Target For Diabetes Found
2013-07-18 08:27:10

Scripps Research Institute An international team led by scientists at The Scripps Research Institute (TSRI) has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes. "Our data should change the current view of how drugs are designed with this and related receptors," said TSRI...

2013-03-07 04:24:08

SAN DIEGO, March 7, 2013 /PRNewswire/ -- Receptos, a biopharmaceutical company focused on developing therapeutic candidates directed to G-protein-coupled receptor (GPCR) targets, announced today that it has successfully determined a novel protein crystal structure of an undisclosed proprietary GPCR drug discovery target for Ono Pharmaceuticals. In December 2011, Ono entered into a technology collaboration to access Receptos' proprietary GPCR structure determination technology platform,...

2012-09-09 22:24:24

WELWYN GARDEN CITY, England and BOSTON, September 10, 2012 /PRNewswire/ -- Update on novel structures and product pipeline to be presented at Biochemical Society and Royal Society of Chemistry meetings Heptares Therapeutics today announces that it has used its StaR(R) technology to solve entirely in-house the first structure of a Family B sub-class G protein-coupled receptor (GPCR). Chief Scientific Officer, Fiona Marshall and Chief Executive...

2010-11-18 17:18:22

Knowing the structure of this and other key cell receptors will help scientists understand brain disorders and may accelerate drug discovery A team led by scientists at The Scripps Research Institute has solved the structure of one of the receptors that responds to the neurotransmitter dopamine. Although dopamine transmission is essential to normal brain functioning, the biological assembly of the molecules involved in this crucial neuronal interplay had not been known"”until now. The...

2010-10-08 02:23:30

The findings may lead to new drugs for cancer, immune disorders and AIDS Researchers have determined the structure of a protein that helps guide blood-forming stem cells, or hematopoetic stem cells. The protein is also one of the main receptors used by the human immunodeficiency virus (HIV) to get inside blood cells. The findings are described in the October 7, 2010 issue of the journal Science. The structure offers a detailed view of how the cell surface receptor, called CXCR4, interacts...