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Latest Receptors Stories

2012-09-20 16:56:31

In the body's ongoing effort to maintain a healthy weight, an arsenal of cellular proteins called androgen receptors is critical for blocking fat accumulation. Now researchers reporting in the September issue of the Cell Press Journal Chemistry & Biology have discovered that naturally occurring steroids called glucocorticoids can thwart the receptors' activity, ultimately encouraging fat buildup. "This has implications in this era of an obesity epidemic," says senior author Dr. Michael...

2012-09-09 22:24:24

WELWYN GARDEN CITY, England and BOSTON, September 10, 2012 /PRNewswire/ -- Update on novel structures and product pipeline to be presented at Biochemical Society and Royal Society of Chemistry meetings Heptares Therapeutics today announces that it has used its StaR(R) technology to solve entirely in-house the first structure of a Family B sub-class G protein-coupled receptor (GPCR). Chief Scientific Officer, Fiona Marshall and Chief Executive...

2012-07-31 10:50:00

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this tumor-suppressive effect, potentially sparking the formation of lung cancer. The findings, published July 24 in the Journal of the...

2012-06-18 02:22:20

VANCOUVER, June 18, 2012 /PRNewswire/ - Amarc Resources Ltd. ("Amarc" or the "Company") (TSX Venture: AHR; OTCBB: AXREF) announces assay results from a further 20 delineation drill holes completed at the Newton gold discovery, south-central British Columbia. The new results from the Newton bulk tonnage gold system bring the total number of holes with important gold intercepts to 67. Delineation drilling of the Newton gold discovery commenced in late September 2011 and has...

2011-12-19 16:10:54

UC Riverside discovery creates new blueprint for engineering drought tolerant crops. When a plant encounters drought, it does its best to cope with this stress by activating a set of protein molecules called receptors. These receptors, once activated, turn on processes that help the plant survive the stress. A team of plant cell biologists has discovered how to rewire this cellular machinery to heighten the plants' stress response — a finding that can be used to engineer crops to...

2011-11-24 11:40:32

Scientists studying longevity thought it might be good to lack a copy of a gene, called IGF1 receptor, that is important in insulin signaling. Previous studies showed invertebrates that lacked the copy lived longer, even if their bodies were less responsive to insulin, the hormone that lowers blood sugar. A new study from The University of Texas Health Science Center San Antonio challenges this. Knocking out one copy of the gene failed to increase the life span of male mice, and it only...

2011-08-11 22:06:11

Cancer needs blood. In fact, some cancer medications work solely to slow or prevent cancer cells from creating new capillaries, choking off their much-needed blood and nutrient supply to halt the growth of tumors. In a paper published online Aug. 8 in the Proceedings of the National Academy of Sciences, researchers at Stanford University describe the creation of a new type of engineered protein that is significantly more effective at preventing the formation of blood vessels by targeting not...

2011-08-01 12:49:20

How do cells know where to position themselves and where to accumulate in order to carry out their functions correctly within each organ? Researchers with the Colorectal Cancer Lab at IRB Barcelona have revealed the molecular mechanisms responsible for organizing the intestinal epithelium into distinct comportments, defined by frontiers or territories. The study, headed by Eduard Batlle, coordinator of the Oncology Programme at IRB Barcelona and ICREA Research Professor, is published in...

2011-06-17 02:01:43

There are ten microbial cells for every one human cell in the body, and microbiology dogma holds that there is a tight barrier protecting the inside of the body from outside invaders, in this case bacteria. Bacterial pathogens can break this barrier to cause infection and senior author Jeffrey Weiser, MD, professor of Microbiology and Pediatrics from the Perelman School of Medicine at the University of Pennsylvania, and first author Thomas Clarke, PhD, a postdoctoral fellow in the Weiser lab,...

2011-03-31 22:45:25

Biologists at UC San Diego have identified the molecular mechanisms triggered by starvation in fruit flies that enhance the nervous system's response to smell, allowing these insects and presumably vertebrates"”including humans"”to become more efficient and voracious foragers when hungry. Their discovery of the neural changes that control odor-driven food searches in flies, which they detail in a paper in the April 1 issue of the journal Cell, could provide a new way to...