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Latest Receptors Stories

2011-03-07 13:02:01

Critical aspect of cell signaling described today at Biophysical Society Meeting in Baltimore New findings from researchers at Harvard Medical School in Boston and the Hospital for Sick Children in Toronto may shed light on the mechanisms that regulate the organization of receptors on the cell surface, a critical aspect of cell signaling not well understood at this time. The group reports on their use of the macrophage protein CD36, a clustering-responsive class B scavenger receptor, as a...

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2011-01-20 11:40:00

Researchers have for the first time mapped the complex choreography used by the immune system's T cells to recognize pathogens while avoiding attacks on the body's own cells. The researchers found that T cell receptors "“ molecules located on the surface of the T cell "“ first bind with the antigen on the pathogen-invaded cell. That initiates a signaling process which leads a co-receptor on the T cell to also bind with the molecule that presents the antigen, amplifying the effect....

2010-11-18 17:23:51

It may have been 1 billion years since plants and animals branched apart on the evolutionary tree but down through the ages they have developed strikingly similar mechanisms for detecting microbial invasions and resisting diseases. This revelation was arrived at over a period of 15 years by teams of researchers from seemingly disparate fields who have used classical genetic studies to unravel the mysteries of disease resistance in plants and animals, according to a historical overview that...

2010-10-08 02:22:15

In a technical tour de force, structural biologists funded by the National Institutes of Health have determined the three-dimensional structure of a molecule involved in HIV infection and in many forms of cancer. The high-resolution structure sheds light on how the molecule functions and could point to ways to control its activity, potentially locking out HIV and stalling cancer's spread. The molecule, CXCR4, is part of a large family of proteins called G-protein coupled receptors (GPCRs)....

2010-08-26 12:53:59

A collaborative team of scientists led by researchers at The Medical College of Wisconsin, in Milwaukee, has used the tools of structural biology to understand how a synthetic chemical mimics abscisic acid (ABA), a key stress hormone that helps plants cope with adverse environmental conditions such as drought. The results are published online in Nature Structural & Molecular Biology in advance of print publication later. For years scientists have searched for practical ways to use ABA...

2010-07-16 17:32:00

LOS ANGELES, July 16 /PRNewswire/ -- Human erythropoietin (EPO) is a potent neuroprotective agent for multiple brain disorders, including stroke, brain and spinal cord injury, and Parkinson's disease. However, EPO drug development for the brain is limited, because EPO does not cross the blood-brain barrier (BBB). In acute stroke or brain injury, the BBB is intact in the early hours after the insult when neuroprotection is still possible. Therefore, large molecule biopharmaceuticals such as...

2010-06-22 02:13:54

Pulmonary arterial hypertension (PAH) is a progressive disease, marked by shortness of breath and fatigue which can be fatal if untreated. Increased pressure in the pulmonary artery and its branches is associated with dysfunctional growth control of endothelial and smooth muscle cells leading to excessive thickening of the blood vessel wall, obliteration of the lumen and right heart failure. BMP (bone morphogenetic protein) receptors play an important role in preventing excess growth of...

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2010-03-31 14:27:54

T cell receptors are among the most important molecules in the immune system because of their role in recognizing the antigens that signal such threats as viruses and cancer. The receptors must also distinguish these threats from the body's own cells to avoid triggering an unwanted immune system response. Recognition requires direct physical contact between the receptor and the antigen. Researchers attempting to understand this critical mechanism, therefore, have been studying such factors as...

2010-03-24 10:27:03

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes. The insulin receptor is a large protein on the surface of cells to which the hormone insulin binds. Insulin controls when and how glucose is used in the human body. Understanding how insulin interacts with the insulin receptor is crucial to the development of treatments for diabetes. Australian scientists revealed the...

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2010-03-12 11:14:35

Conventional biological wisdom holds that living cells  interact with their environment through an elaborate network of chemical signals. As a result many therapies for the treatment of cancer and other diseases in which cell behavior goes awry focus on drugs that block or disrupt harmful chemical signals. Now, a new road for future therapies may have been opened with scientific evidence for a never seen before way in which cells can also sense and respond to physical forces. A team of...