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Latest recombination Stories

2011-10-24 10:15:15

Findings suggest how cancer cells can become resistant to DNA damage-inducing treatments An international team of scientists led by UC Davis researchers has discovered that DNA repair in cancer cells is not a one-way street as previously believed. Their findings show instead that recombination, an important DNA repair process, has a self-correcting mechanism that allows DNA to make a virtual u-turn and start over. The study's findings, which appear in the Oct. 23 online issue of the...

2011-10-06 13:08:46

In children with genomic disorders, often a gamete — egg or sperm — has gone disastrously awry with either a duplication or deletion of genetic material that results in physical and neurological problems for the subsequent child. Previous studies have identified a procedure called nonallelic homologous recombination, which occurs during meiosis or sexual cell division, as the event that most commonly occurs and results in this mistake in DNA. Researchers from Baylor College...

2011-09-01 15:32:02

It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that certain BRCA1 mutations result in excessive, uncontrolled DNA repair, which challenges the prior assumption that mutations in BRCA1 only contribute to breast cancer through a reduction in...

2011-08-08 06:43:56

The human genome is peppered with repeated DNA elements that can vary from a few to thousands of consecutive copies of the same sequence. During meiosis"”the cell division that produces sperm and eggs"”repetitive elements place the genome at risk for dangerous rearrangements from genome reshuffling. This recombination typically does not occur in repetitive DNA, in part because much of it is assembled into specialized heterochromatin. Other mechanisms that restrain recombination in...

2011-07-25 13:30:58

UCLA life scientists and colleagues have produced one of the first high-resolution genetic maps for African American populations. A genetic map reveals the precise locations across the genome where DNA from a person's father and mother have been stitched together through a biological process called "recombination." This process results in new genetic combinations that are then passed on to the person's children. The new map will help disease geneticists working to map genetic diseases in...

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2011-07-21 05:15:00

Scientists at the University of Oxford and Harvard Medical School have constructed the world's most detailed genetic map. The map specifies the precise areas in the genetic material of a sperm or egg, where the DNA from the mother and father has been reshuffled in order to produce this single reproductive cell. The biological process in which this reshuffling occurs is known as "recombination." Although most genetic maps have been developed from people of European ancestry, this new map...

2011-05-31 16:57:20

Delineation of the origin of the retrovirus known as XMRV from the genomes of laboratory mice indicates that the virus is unlikely to be responsible for either prostate cancer or chronic fatigue syndrome in humans, as has been widely published. The virus arose because of genetic recombination of two mouse viruses. Subsequent infection of lab experiments with XMRV formed the basis of the original association. Reporting in Science, Vinay Pathak, Ph.D., and his research team from the National...

2011-04-19 13:07:14

Berkeley Lab Scientists Discover Dynamic Double-Strand Break Repair in Heterochromatin DNA is under constant attack, from internal factors like free radicals and external ones like ionizing radiation. About 10 double-strand breaks "“ the kind that snap both backbones of the double helix "“ occur every time a human cell divides. To prevent not only gene mutations but broken chromosomes and chromosomal abnormalities known to cause cancer, infertility, and other diseases in humans,...

2011-04-07 16:50:16

Thematic program focuses on DNA replication, recombination and repair DNA's role as the master blueprint of the cell means that even small sequence changes can have catastrophic consequences. For this reason, much of our understanding of cancer development comes from studying how cells copy DNA and repair sequence errors -- and how these processes can go wrong. Next week, a thematic program at the American Society for Biochemistry and Molecular Biology's annual meeting at the Experimental...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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