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Latest Regulation of gene expression Stories

2012-10-09 10:50:36

Findings question earlier studies and shed light on fundamental cellular process Scientists at the Gladstone Institutes have mapped the precise frequency by which genes get turned on across the human genome, providing new insight into the most fundamental of cellular processes–and revealing new clues as to what happens when this process goes awry. In a study being published this week online in the Proceedings of the National Academy of Sciences, Gladstone Investigator Leor...

2012-08-27 11:45:43

Researchers show how repressor proteins ensure accurate gene expression by thwarting histone exchange Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the activators, keeps DNA open to enzymes that transcribe DNA into RNA. Their repressor opponents antagonize that effort by twisting DNA into an inaccessible coil around histone proteins, an amalgam called chromatin, effectively blocking access to DNA by enzymes that elongate an RNA strand. Both...

Seeds Of Defense Being Planted
2012-08-08 07:16:52

Salk study finds stress triggers widespread epigenetic changes that aid in disease resistance It was long thought that methylation, a crucial part of normal organism development, was a static modification of DNA that could not be altered by environmental conditions. New findings by researchers at the Salk Institute for Biological Studies, however, suggest that the DNA of organisms exposed to stress undergo changes in DNA methylation patterns that alter how genes are regulated. The...

Library of Genetic Circuits Developed For Scientific Functions
2012-08-03 13:24:55

April Flowers for redOrbit.com - Your Universe Online For about a dozen years, synthetic biologists have been working on designing genetic circuits to perform novel functions such as manufacturing new drugs, producing fuel or even programming the suicide of cancer cells. Many factors have to be controlled for this dream to become a reality. Scientists have to gain control over complex genetic and cellular components, including genes and the regulatory proteins, called transcription...

2012-06-29 10:40:39

'Paper of the week' shows that a master regulator protein brings plethora of coactivators to gene expression sites Molecular geneticists call big boss proteins that switch on broad developmental or metabolic programs "master regulators," as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6α (ATF6α) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress,...

2012-04-12 22:22:23

Caltech biologists scour mouse genome for genes and markers that lead to T cells What happens to a stem cell at the molecular level that causes it to become one type of cell rather than another? At what point is it committed to that cell fate, and how does it become committed? The answers to these questions have been largely unknown. But now, in studies that mark a major step forward in our understanding of stem cells' fates, a team of researchers from the California Institute of...

2012-04-11 22:30:42

Anyone who's tried a weekend home improvement project knows that to do a job right, you've got to have the right tools. For cells, these "tools" are proteins encoded by genes. The right genes for the job are turned on only in the specific cells where they are needed. And every cell in your body has a specific job to do. Cells in your pancreas have to produce insulin, while cells in the retina of your eye must be able to sense light and color. Like using the wrong tool for the job, if the...

2012-02-16 18:13:38

Writing in the February 17, 2012 issue of the journal Cell, researchers at the Ludwig Institute for Cancer Research, the University of California, San Diego School of Medicine and the Toronto Western Research Institute peel away some of the enduring mystery of how zygotes or fertilized eggs determine which copies of parental genes will be used or ignored. In developing humans and other mammals, not all genes are created equal — or equally used. The expression of certain genes, known...

2012-02-14 15:30:35

Personal change can redefine or even save your life–especially if you are one of a hundred yeast cell clones clinging to the skin of a grape that falls from a sun-drenched vine into a stagnant puddle below. By altering which genes are expressed, cells with identical genomes like these yeast clones are able to survive in new environments or even perform different roles within a multicellular organism. Changes in gene expression can occur in a multitude of ways, but a team of...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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