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Latest Regulation of gene expression Stories

2011-12-22 15:35:16

Transcriptional elongation control takes on new dimensions as Stowers researchers find gene class-specific elongation factors Life is complicated enough, so you can forgive the pioneers of DNA biology for glossing over transcriptional elongation control by RNA polymerase II, the quick and seemingly bulletproof penultimate step in the process that copies the information encoded in our DNA into protein-making instructions carried by messenger RNA. In a new report appearing in the Dec. 23,...

2011-11-15 09:46:57

Researchers at the Keck School of Medicine of the University of Southern California (USC) have discovered key processes by which estrogen, the female sex hormone, activates genes in breast-cancer cells. Greater understanding of how this occurs is expected to eventually lead to new treatments for the disease. Michael R. Stallcup, Ph.D., professor and chair of the Keck School's Department of Biochemistry and Molecular Biology, was the senior author, and Kwang Won Jeong, Ph.D., a postdoctoral...

2011-11-10 18:35:59

Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine say this process is even more complex than previously thought, with regulated genes actually relocated to other, more conducive places in the cell nucleus. "When regulated gene transcription goes awry, many human...

2011-06-21 18:34:17

A team of scientists, led by researchers at the University of California, San Diego School of Medicine, have uncovered a novel mechanism regulating gene expression and transcription linked to Spinocerebellar ataxia 7, an inherited neurological disorder. The discovery promises to have broad ramifications, suggesting that abundant non-coding transcripts of ribonucleic acid (RNA) may be key players in neurological development and function, and could be powerful targets for future clinical...

2011-03-21 16:37:31

If a big bunch of your brain cells suddenly went rogue and decided to become fat cells, it could cloud your decision-making capacity a bit. Fortunately, early in an organism's development, cells make firm and more-or-less permanent decisions about whether they will live their lives as, say, skin cells, brain cells or, well, fat cells. Those decisions essentially boil down to which proteins, among all the possible candidates encoded in a cell's genes, the cell will tend to make under ordinary...

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2011-03-03 09:55:00

Vive le difference? Not at the level of DNA. Men must increase gene expression on their lone X-chromosome to match the two X's possessed by women. A new study explains just how men manage to do that. What makes a man? His clothes? His car? His choice of scotch? The real answer, says Brown University biologist Erica Larschan, is the newly understood activity of a protein complex that, like a genetic power tool, gives enzymes on the X-chromosome an extra boost to increase gene expression. The...

2011-02-17 08:00:00

MOUNTAIN VIEW, Calif., Feb. 17, 2011 /PRNewswire/ -- Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced the release of the Tet-Express Inducible Expression System, which provides the quickest and simplest Tet-inducible expression technology yet. At the heart of this new system is a cell membrane-permeable version of Clontech's Tet-Off® Advanced transcriptional activator protein (the Tet-Express transactivator) that can enter cells...

2011-01-13 14:25:06

In the case of DNA, the package can be as important as its contents, new work with fruit flies reveals. In 2003, the year a complete draft of the human genome was released, the U.S. National Human Genome Research Institute launched the ENCODE project (ENCyclopedia of DNA Elements), to develop an encyclopedia of the epigenome, that is, of all of the many factors that can change the expression of the genes without changing the genes. Four years later, the National Institutes of Health funded...

2010-12-23 02:22:19

When the best therapies fail, drug combos offer new hope Researchers at The Wistar Institute announce the release of an online tool that will help scientists find "gene promoters""”regions along a DNA strand that tell a cell's transcription machinery where to start reading in order to create a particular protein. The Mammalian Promoter Database (MPromDb) integrates the genome sequencing data generated at Wistar with publicly available data on human and mouse genomics. MPromDb pinpoints...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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