Latest Regulation of gene expression Stories

2009-11-20 12:11:29

A team led by Penn State's Ross Hardison, T. Ming Chu Professor of Biochemistry and Molecular Biology, has taken a large step toward unraveling how regulatory proteins control the production of gene products during development and growth. Working with collaborators including Drs. Mitchell Weiss and Gerd Blobel at Children's Hospital of Philadelphia, they focused specifically on the complex process of producing red blood cells (erythrocytes). These cells contain large amounts of hemoglobin, a...

2009-11-05 09:49:24

EMBL scientists take new approach to predict gene expression Embryonic development is like a well-organized building project, with the embryo's DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes. These patterns of gene expression are controlled by transcription factors: molecules which bind to stretches of DNA called cis-regulatory...

2009-11-03 09:22:27

The search for the holy grail of regenerative medicine"”the ability to "grow back" a perfect body part when one is lost to injury or disease"”has been under way for years, yet the steps involved in this seemingly magic process are still poorly understood. Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic...

2009-10-29 15:14:35

Johns Hopkins researchers uncover new kink in gene control Since the completion of the human genome sequence, a question has baffled researchers studying gene control: How is it that humans, being far more complex than the lowly yeast, do not proportionally contain in our genome significantly more gene-control proteins? Now, a collaborative effort at the Johns Hopkins School of Medicine to examine protein-DNA interactions across the whole genome has uncovered more than 300 proteins that...

2009-10-10 07:42:26

All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. The set of proteins synthesized by a cell in turn determines its structure and behavior, and enables it to survive and reproduce. So it is crucial that the appropriate stretches of DNA are transcribed in each cell type. In the Oct. 9 issue of the journal Nature, a team of researchers at the Gene Center of...

2009-09-22 13:24:40

Single-molecule tests help scientists address long-standing questions The tools of biochemistry have finally caught up with lactose repressor protein. Biologists from Rice University in Houston and the University of Florence in Italy this week published new results about "lac repressor," which was the first known genetic regulatory protein when discovered in 1966. Using cutting-edge techniques, the scientists tied together two segments within individual molecules of lactose repressor protein....

2009-09-02 07:53:22

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institute published in Cell Metabolism. The researchers believe that these "Ëœepigenetic mutations' might have a key part to play in the development of the disease.Type II diabetes is characterized by a lower sensitivity to insulin in muscles and organs, and a reduced...

2009-07-30 13:45:54

The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.When these nanoscale protein machines encounter obstacles as they move along the DNA, they stall, often for minutes, and even backtrack as they transcribe DNA that is tightly wound to fit inside the cell's nucleus.The findings come from delicate measurements of molecular-scale forces exerted on individual proteins that move along...

2009-06-16 09:34:58

For many years scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining the fate of genes. Although they are not anchored in the DNA, they can even be passed on to subsequent generations to a certain extent. Intensive research in recent years has shown that these mechanisms "“ bundled under the term epigenetics, are very multifaceted and...

2009-06-11 07:38:02

Scientists say they have taken a big step toward developing a new generation of drugs that treat diseases by turning genes on and off. The medications would boost the production of proteins in genes working at abnormally low levels or shut off genes that produce an abnormal protein linked to disease, researchers said. Molecules cause genes to be active and churn out proteins called transcriptional activators, which are named for their role in controlling a process called transcription,...

Word of the Day
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'