Quantcast

Latest Regulation of gene expression Stories

2009-06-03 14:22:13

In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.Scientists at the University of Michigan and the University of California at Berkeley have taken a step forward on that route by developing small molecules that mimic the behavior and function of a much larger and more complicated natural...

2009-05-26 10:32:23

Even microbes are governed by the principle of supply and demand "“ at least at the genetic level. Not all of their gene products, the blueprints for proteins, are required at all times. That means most of their genes only become active when they are needed, as is the case in higher organisms. In the simplest case, a transcription factor will activate the gene in question at the right time. Genes that are regulated in a somewhat more complex manner, on the other hand, are kept inactive...

2009-05-15 11:45:19

Dartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15.Research on the relationship between clocks and temperature, reported in Cell, offers insight into a longstanding puzzle of temperature compensation: why the 24-hour circadian rhythm does not change with temperature when metabolism is so affected.A related study, in...

2009-04-17 11:19:55

The discovery of a new nucleotide in the mouse brain opens the door to a new domain of epigenetic DNA modificationAnyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine "“ the A,T,G and C that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that sometimes replaces cytosine in the famous DNA double helix to regulate which...

2009-01-12 06:00:00

Milestone Achieved A Year Ahead of Schedule ST. LOUIS and RICHMOND, Calif., Jan. 12 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) today announced it has reached a major production capacity milestone as part of its agreement with Sigma-Aldrich Corporation (Nasdaq: SIAL) to commercialize zinc finger nuclease reagents (ZFNs) for research applications. The milestone triggers a payment of $1.0 million to Sangamo. "Reaching this production milestone more than one year ahead...

2008-12-23 14:40:58

A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures. The findings were posted to the online Early Edition of the Proceedings of the National Academy of Science today. The team led by Robb Krumlauf and Leanne Wiedemann set out to understand the...

2008-10-28 15:00:13

Canadian and Hungarian scientists say they've discovered DNA from suicide victims who suffered major depression shows an important chemical modification. Dr. Michael Poulter of the University of Western Ontario led a team of researchers in comparing brain tissue from a group of people who suffered a major depressive disorder and committed suicide, with the brain tissue of people who had died from heart attacks and other causes. The researchers said they found an increased rate of DNA...

2008-08-13 18:00:14

By Ponomarev, Vladimir Recent years have witnessed a remarkable increase in our knowledge and understanding of the genetics and molecular biology of human diseases. During the past 2 decades, technologic innovations revolutionized molecular and cell biology. Significant progress in the understanding of the molecular-genetic mechanisms of many diseases has been achieved with the advent of the modern molecular- biologic assays. The development of transgenic animal models of human diseases,...

a19d2644148eac52461f56a547d015641
2007-03-14 11:50:14

Neurobiologists have discovered a mechanism by which the constantly changing brain retains memories"”from that dog bite to that first kiss. They have found that the brain co-opts the same machinery by which cells stably alter their genes to specialize during embryonic development. Courtney Miller and David Sweatt reported their findings in the March 15, 2007 issue of the journal Neuron, published by Cell Press. Their studies aimed at exploring whether a process called DNA methylation...

7e17a816c9c82431a2e7bef9e426a15f1
2007-02-22 15:30:00

(PHILADELPHIA) -- At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. In an average cell, only about one in ten genes is active, or expressed, at any given moment, with its DNA open to the cell' transcriptional machinery. A dynamic cast of gatekeeper enzymes controls this access to the DNA, adding and removing particular molecules to open or close...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.