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Latest Replication fork Stories

2013-07-16 10:34:16

Breaks in the double-strands of the DNA helix can spell trouble, destabilizing the genome and resulting in changes that drive cancer, antibiotic resistance and, on a more positive note, evolution. Scientists can generate these breaks by a variety of extraneous methods in the laboratory, but Baylor College of Medicine scientists Dr. Philip Hastings and Dr. Susan Rosenberg wondered how such breaks occur without outside help - and how they occur in resting cells not actively making new copies...

2011-10-17 10:19:55

At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin. This dense packing serves to repress or "silence" the DNA sequences within–which could wreck the genome if activated–as well as regulate the activity of nearby genes. When the cell divides, the daughter cells not only inherit a copy of the mother cell's DNA, but also the exact pattern in which that DNA is clumped into heterochromatin. This...

2011-04-16 00:41:30

A Berkeley Lab-led team deciphers the structure of FEN1, a key player in DNA replication and repair DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role. The structure of human FEN1 has now been solved by an international team of scientists led by the...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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